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Titolo:
Glycolipoprotein extract (G-90) from earthworm Eisenia foetida exerts someantioxidative activity
Autore:
Grdisa, M; Popovic, M; Hrzenjak, T;
Indirizzi:
Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia Rudjer Boskovic Inst Zagreb Croatia 10000 Mol Med, Zagreb 10000, Croatia Fac Med Vet, Dept Biol, Zagreb, Croatia Fac Med Vet Zagreb CroatiaFac Med Vet, Dept Biol, Zagreb, Croatia
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 821 - 825
SICI:
1095-6433(200104)128:4<821:GE(FEE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; ATHEROSCLEROSIS; PATHOGENESIS; MECHANISMS;
Keywords:
antioxidant; Eisenia foetida; glycolipoprotein; hydrogen peroxide; cell lines; proliferation; G-90; earthworm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Grdisa, M Rudjer Boskovic Inst, Div Mol Med, Bijenicka 54, Zagreb 10000, Croatia Rudjer Boskovic Inst Bijenicka 54 Zagreb Croatia 10000 Croatia
Citazione:
M. Grdisa et al., "Glycolipoprotein extract (G-90) from earthworm Eisenia foetida exerts someantioxidative activity", COMP BIOC A, 128(4), 2001, pp. 821-825

Abstract

Antioxidants protect DNA, proteins and lipids in the body from damage. These types of damages are a major contributor to aging and to degenerative diseases such as cancer, cardiovascular disease, immune-system decline, braindysfunction and cataracts. The effect of glycolipoprotein extract of Eisenia foetida (G-90) as an antioxidant was investigated in cultured human fibroblasts and epithelial cells. After treatment of the cells with H2O2 for 4 h, G-90 completely allows the cells to recover and stimulated their growth. When the cells were incubated with G-90 48 h before the treatment with H2O2, the oxidative damage of the cells did not occur. Thus, G-90 had an apparent protective effect against the toxicity of H2O2 and stimulated the growth of the cells. Ascorbic acid, a known antioxidant, did not allow the growth of the cells to recover after damage nor did it protect them, unless it was added simultaneously with H2O2. The antioxidative activity of G-90, together with its antibacterial and mitogen activities, could be useful in the study of G-90 as a wound-healing agent. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:32:21