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Titolo:
Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation
Autore:
Kubli, S; Feihl, F; Waeber, B;
Indirizzi:
Univ Hosp, Div Clin Pathophysiol & Med Teaching, CH-1011 Lausanne, Switzerland Univ Hosp Lausanne Switzerland CH-1011 ng, CH-1011 Lausanne, Switzerland
Titolo Testata:
CLINICAL PHARMACOLOGY & THERAPEUTICS
fascicolo: 4, volume: 69, anno: 2001,
pagine: 238 - 244
SICI:
0009-9236(200104)69:4<238:BWNETA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN BLOOD-FLOW; ENDOTHELIAL FUNCTION; ESSENTIAL-HYPERTENSION; FOREARM VASCULATURE; REACTIVE HYPEREMIA; HEART-FAILURE; ATENOLOL; DYSFUNCTION; ARTERIES; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Waeber, B Univ Hosp, Div Pathophysiol, PPA BH-19, CH-1011 Lausanne, Switzerland Univ Hosp PPA BH-19 Lausanne Switzerland CH-1011 e, Switzerland
Citazione:
S. Kubli et al., "Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation", CLIN PHARM, 69(4), 2001, pp. 238-244

Abstract

Nebivolol is a selective beta(1)-adrenoceptor blocker that has a vasorelaxant activity thought to be the result of a facilitation of the release of nitric oxide from the endothelium. This study was undertaken in 12 healthy male volunteers to assess whether this compound increases the vasodilatory response to acetylcholine when administered orally at a dose commonly recommended for the treatment of cardiovascular diseases. The subjects were randomly allocated to an 8-day treatment with nebivolol(5 mg once a day) and atenolol (50 mg once a day) according to a cross-over design. The two treatments were separated by a 1-week washout period. On the first and the last dayof each treatment phase, both before drug administration and 3 hours afterdrug administration, the forearm skin blood flow response to acetylcholineapplied by iontophoresis was determined with the use of a laser Doppler scanner imaging system. The reactivity to acetylcholine was significantly increased 3 hours after the administration of nebivolol on both the first and the last day of treatment, whereas atenolol had no effect on this parameter. These data therefore indicate that nebivolol, but not atenolol, enhances the vasorelaxant activity of acetylcholine in the skin vascular bed; this is compatible with a facilitation by this beta-blocker of the endothelium-dependent vasodilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:27:31