Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHRONIC CAREGIVING STRESS ALTERS PERIPHERAL-BLOOD IMMUNE PARAMETERS -THE ROLE OF AGE AND SEVERITY OF STRESS
Autore:
PARIANTE CM; CARPINIELLO B; ORRU MG; SITZIA R; PIRAS A; FARCI AMG; DELGIACCO GS; PILUDU G; MILLER AH;
Indirizzi:
MAUDSLEY HOSP & INST PSYCHIAT,DENMARK HILL LONDON SE5 8AZ ENGLAND EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI ATLANTA GA 00000 UNIV CAGLIARI I-09124 CAGLIARI ITALY
Titolo Testata:
Psychotherapy and psychosomatics
fascicolo: 4, volume: 66, anno: 1997,
pagine: 199 - 207
SICI:
0033-3190(1997)66:4<199:CCSAPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; LEUKOCYTE SUBPOPULATIONS; PSYCHIATRIC MORBIDITY; DEPRESSION; HYPERSENSITIVITY; NEUROENDOCRINE; INTERLEUKIN-6; ENDOCRINE; RESPONSES; VICTIMS;
Keywords:
PSYCHONEUROIMMUNOLOGY; PSYCHOLOGICAL STRESS; FAMILY BURDEN; IMMUNE SYSTEM; LYMPHOCYTE SUBSETS; HERPESVIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Pariante et al., "CHRONIC CAREGIVING STRESS ALTERS PERIPHERAL-BLOOD IMMUNE PARAMETERS -THE ROLE OF AGE AND SEVERITY OF STRESS", Psychotherapy and psychosomatics, 66(4), 1997, pp. 199-207

Abstract

Background: To examine the impact of chronic psychological stress on the immune system, a series of cellular and humoral immunological parameters was compared in 18 female caregivers of handicapped people and 18 age- and sexmatched controls. Methods: The immunological parametersincluded assessment of T cell number (T cells, T helper, and T suppressor/cytotoxic) and function (delayed-type cutaneous hypersensitivity), antibody titers for latent herpesviruses (cytomegalovirus and herpessimplex virus 1 and 2), and markers of inflammation (complement C3 and C4 factors and c-reactive protein). Serum immunoglobulins (IgG, IgM,IgA, IgE) and titers for the nonlatent virus roseola were used to control for nonspecific elevations in serum proteins. Results were associated with the age of the investigated subjects, the severity of stress(family burden) and the degree of disability of the handicapped people. Results: Caregivers had a significantly lower percentage of T cells, a significantly higher percentage of T suppressor/cytotoxic cells and a significantly lower T helper:suppressor ratio. Subjects were also analyzed after division into two groups according to the median age (45 years). Compared to their matched controls, older caregivers (mean age = 50.3) also had lower numbers of T cells and T helper cells and higher antibody titers for cytomegalovirus. In addition, in the caregiver population severity of stress was significantly positively correlated with T suppressor/cytotoxic cells and negatively correlated with T helper:suppressor ratio. No other differences in the immune parameters were found between caregivers and controls. Conclusions: The results indicate that psychological stress differentially affects various aspects of the immune system and confirm the relevant role of age and severity of stress in modulating these influences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:04:38