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Titolo:
Leishmania-sand fly interactions controlling species-specific vector competence
Autore:
Sacks, DL;
Indirizzi:
NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CELLULAR MICROBIOLOGY
fascicolo: 4, volume: 3, anno: 2001,
pagine: 189 - 196
SICI:
1462-5814(200104)3:4<189:LFICSV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHLEBOTOMUS-PAPATASI DIPTERA; ANTHROPONOTIC CUTANEOUS LEISHMANIASIS; LUTZOMYIA-LONGIPALPIS DIPTERA; SURFACE LIPOPHOSPHOGLYCAN; MAJOR LIPOPHOSPHOGLYCAN; LIFE-CYCLE; PSYCHODIDAE; MIDGUT; DONOVANI; INFECTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sacks, DL NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 is Lab, NIH, Bethesda, MD 20892 USA
Citazione:
D.L. Sacks, "Leishmania-sand fly interactions controlling species-specific vector competence", CELL MICROB, 3(4), 2001, pp. 189-196

Abstract

Leishmaniasis is caused by a wide range of parasites that are transmitted by an even wider range of sand fly vectors. The phlebotomine vectors of Leishmaniasis are in some cases only permissive to the complete development ofthe species of Leishmania that they transmit in nature. The parasite-sand fly interactions that control this specificity are related to differences in the ability of the parasite to inhibit or to resist killing by proteolytic enzymes released into the midgut soon after blood feeding, and/or to maintain infection in the mid-gut during excretion of the digested blood meal. In each case, surface expressed or released phosphoglycan-containing molecules appear to promote parasite survival. The evidence that the surface lipophosphoglycan (LPG) mediates promastigote attachment to the mid-gut epithelium so as to prevent their loss during blood-meal excretion is especially strong based on the comparison of development in sand flies using LPG-deficient mutants. LPG displays interspecies polymorphisms in their phosphoglycandomains that in most cases can fully account for species-specific vector competence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:28:14