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Titolo:
Impact of contrast agent type (ionic versus nonionic) used for coronary angiography on angiographic, electrocardiographic, and clinical outcomes following thrombolytic administration in acute myocardial infarction
Autore:
Gibson, CM; Kirtane, AJ; Murphy, SA; Marble, SJ; de Lemos, JA; Antman, EM; Braunwald, E;
Indirizzi:
Harvard Clin Res Inst, Boston, MA 02215 USA Harvard Clin Res Inst Boston MA USA 02215 Res Inst, Boston, MA 02215 USA Univ Calif San Francisco, Dept Med, Div Cardiovasc, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA asc, San Francisco, CA USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 1, volume: 53, anno: 2001,
pagine: 6 - 11
SICI:
1522-1946(200105)53:1<6:IOCAT(>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIMI FRAME COUNT; RANDOMIZED TRIAL; THROMBUS FORMATION; UNSTABLE ANGINA; MEDIA; ANGIOPLASTY; RISK; COMPLICATIONS; ABCIXIMAB; FLOW;
Keywords:
acute myocardial infarction; contrast agent; angiography; coronary blood flow; thrombolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gibson, CM Harvard Clin Res Inst, 900 Commonwealth Ave,2nd Floor, Boston, MA 02215 USA Harvard Clin Res Inst 900 Commonwealth Ave,2nd Floor Boston MAUSA 02215
Citazione:
C.M. Gibson et al., "Impact of contrast agent type (ionic versus nonionic) used for coronary angiography on angiographic, electrocardiographic, and clinical outcomes following thrombolytic administration in acute myocardial infarction", CATHET C IN, 53(1), 2001, pp. 6-11

Abstract

The goal of this study was to examine the relationship between contrast agent type (ionic vs, nonionic) and angiographic, electrocardiographic, and clinical outcomes after thrombolytic administration. Ionic or nonionic contrast agents were selected in a nonrandomized fashion for 90-min angiography and percutaneous coronary intervention (PCI) following thrombolytic administration in the TIMI 14 trial [tissue plasminogen activator (tPA) or reteplase (rPA) vs. low-dose lytic + abciximab]. There was no relationship betweencontrast agent type and overall patency, rate of TIMI grade 3 flow, or corrected TIMI frame counts (CTFCs) in open culprit arteries and in post-PCI patency rates or post-PCI CTFCs. In patients treated with ionic contrast, ejection fractions at 90 min were slightly but significantly lower (56.2 +/- 16.5, n = 122, vs. 59.8 +/- 14.4, n = 322; P = 0.02), chest pain duration was longer (2.8 +/- 4.1 hr, n = 255, vs. 1.7 +/- 3.6, n = 550; P = 0.0003), and complete ST segment resolution was less frequent (41.5% vs. 50.8%; P = 0.04). While there was no difference in epicardial blood flow, ionic contrast agent use was associated with poorer ST segment resolution, longer chestpain duration, and poorer ejection fractions, perhaps as a result of microvascular dysfunction. Cathet Cardiovasc Intervent 2001;53:6-11. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:58:11