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Titolo:
Is the cancer protective effect correlated with growth inhibitions by green tea (-)-epigallocatechin gallate mediated through an antioxidant mechanism?
Autore:
Cutter, H; Wu, LY; Kim, C; Morre, DJ; Morre, DM;
Indirizzi:
Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 ds & Nutr, W Lafayette, IN 47907 USA Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Pharmacol, W Lafayette, IN 47907 USA
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 162, anno: 2001,
pagine: 149 - 154
SICI:
0304-3835(20010126)162:2<149:ITCPEC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADH OXIDASE; CAMELLIA-SINENSIS; TRANSFORMED-CELLS; TUMOR INITIATION; MOUSE SKIN; FLAVONOIDS; CATECHINS; PROMOTION; CULTURE;
Keywords:
(-)-epigallocatechin gallate; antioxidant; cell proliferation; cell surface NADH oxidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Morre, DM Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA PurdueUniv W Lafayette IN USA 47907 W Lafayette, IN 47907 USA
Citazione:
H. Cutter et al., "Is the cancer protective effect correlated with growth inhibitions by green tea (-)-epigallocatechin gallate mediated through an antioxidant mechanism?", CANCER LETT, 162(2), 2001, pp. 149-154

Abstract

The preferential inhibition by (-)-epigallocatechin gallate (EGCg) of growth of cancer cells (e.g. HeLa) in culture correlates with the ability of EGCg to inhibit a growth-related, cell surface hydroquinone oxidase with protein disulfide-thiol interchange activity (tNOX) measured as an NADH oxidaseand specifically associated with tumorigenically-transformed cells and tissues. tNOX is reduced or absent from the surface of non-cancer cells. Various oxidizing conditions known to render other antioxidants such as thiols, ascorbate and vitamin E ineffective did not reduce the effectiveness of EGCg in inhibiting either the tNOX activity or the growth of HeLa cells. Only after Fenton reaction with iron catalysis in the presence of hydrogen peroxide was the effectiveness of the EGCg reduced. We conclude that it is unlikely that the anticancer action of green tea EGCg on the tNOX protein is mediated through antioxidant properties of EGCg. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:36:12