Catalogo Articoli (Spogli Riviste)

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Titolo:
Apoptosis associated with esophageal adenocarcinoma: influence of photodynamic therapy
Autore:
McGarrity, TJ; Peiffer, LP; Granville, DJ; Carthy, CM; Levy, JG; Khandelwal, M; Hunt, DWC;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst,Div Gastroenterol & Hepatol,Gastroenterol Sect, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 oenterol Sect, Hershey, PA 17033 USA QLT PhotoTherapeut Inc, Vancouver, BC, Canada QLT PhotoTherapeut Inc Vancouver BC Canada ut Inc, Vancouver, BC, Canada Univ British Columbia, Fac Sci, Vancouver, BC V5Z 1M9, Canada Univ BritishColumbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 163, anno: 2001,
pagine: 33 - 41
SICI:
0304-3835(20010210)163:1<33:AAWEAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE LYMPHOMA-CELLS; DNA FRAGMENTATION; ACTIVATION; P53; DEATH; BCL-2; CARCINOMA; CANCER; OVEREXPRESSION; ACCUMULATION;
Keywords:
apoptosis; caspase 3; photodynamic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: McGarrity, TJ Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst,Div Gastroenterol & Hepatol,Gastroenterol Sect, POB 850,500 Univ Dr,MC HO45, Hershey, PA 17033 USA Penn State Univ POB 850,500 Univ Dr,MC HO45 Hershey PA USA 17033
Citazione:
T.J. McGarrity et al., "Apoptosis associated with esophageal adenocarcinoma: influence of photodynamic therapy", CANCER LETT, 163(1), 2001, pp. 33-41

Abstract

Tumor cell death in vitro by photodynamic therapy (PDT) has been related to the induction of apoptosis, We measured and compared changes in apoptosisand caspase 3 activity, an effector of apoptosis, in normal and neoplasticesophageal tissues during PDT, Apoptosis index, caspase 3 cleavage activity, pro-caspase 3, p53, and bcl-2 levels were measured in normal and neoplastic tissues of patients with esophageal adenocarcinoma before, during, and after PDT with Photofrin. The apoptotic index was greater in carcinoma tissue compared to adjacent normal tissues. In concert, pro-caspase 3 immunoreactivity was absent and caspase 3-like cleavage activity was over 30-fold greater in carcinoma tissue compared to normal esophageal tissues. These parameters were unaffected by PDT. Variable changes in bcl-2 and p53 immunoreactivity were noted in normal and carcinoma tissues during PDT, Greater levels of apoptosis and caspase 3 activity are hallmarks of esophageal adenocarcinoma compared to normal esophageal tissue. These differences were unaffected by PDT. This may be due to the fact that tissues were obtained 72 h post-PDT therapy. Changes in these parameters may have occurred early after PDTtherapy. An assessment of apoptosis and caspase 3 activity prior to 72 h post-PDT may provide further insight into the mechanism involved, although no sustained effects on these parameters by PDT were noted. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:43:53