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Titolo:
Natural killer cell tumoricidal activity and deterioration of lung tumor metastasis in silicotic mice and stressed silicotic mice
Autore:
Ishihara, Y; Iijima, H; Matsunaga, K;
Indirizzi:
Tokyo Womens Med Univ, Sch Med, Dept Hyg & Publ Hlth 1, Shinjuku Ku, Tokyo1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 injuku Ku, Tokyo1628666, Japan Kureha Chem Ind Co Ltd, Biomed Res Labs, Shinjuku Ku, Tokyo 1628503, JapanKureha Chem Ind Co Ltd Tokyo Japan 1628503 juku Ku, Tokyo 1628503, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 163, anno: 2001,
pagine: 11 - 15
SICI:
0304-3835(20010210)163:1<11:NKCTAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-BOUND POLYSACCHARIDE;
Keywords:
spletic NK cell activity; silicosis; Lewis lung carcinoma; lung metastasis; splenic cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Ishihara, Y Tokyo Womens Med Univ, Sch Med, Dept Hyg & Publ Hlth 1, Shinjuku Ku, Tokyo1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 okyo1628666, Japan
Citazione:
Y. Ishihara et al., "Natural killer cell tumoricidal activity and deterioration of lung tumor metastasis in silicotic mice and stressed silicotic mice", CANCER LETT, 163(1), 2001, pp. 11-15

Abstract

Aim of this study is to explore the role of splenic NK cells in the lung metastasis in the silicotic mice. The number of metastatic foci increased 1.5-fold and 1.8-fold in the silicotic and stressed silicotic mice compared with the control mice. Treatment with an immunomodulator reduced the rate oftumor metastasis in silicotic mice with or without stresses, while their NK cell activity was normalized. Decrease of NK cell activity on the day of tumor inoculation but not on the post-inoculation days seems to be a major factor for predicting the extent of tumor metastasis in the silicotic and stressed silicotic mice. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:21:05