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Titolo:
Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability
Autore:
Burkle, A;
Indirizzi:
Univ Newcastle Upon Tyne, Newcastle Gen Hosp, Wolfson Res Ctr, IHE,Inst Hlth Elderly,Dept Gerontol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, EnglandUniv Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE4 6BE
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 163, anno: 2001,
pagine: 1 - 5
SICI:
0304-3835(20010210)163:1<1:PADDPM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(ADP-RIBOSE) POLYMERASE GENE; SISTER-CHROMATID EXCHANGE; DEFICIENT CELL-LINES; GAMMA-IRRADIATION; EXCISION-REPAIR; MICE RESISTANT; APOPTOSIS; OVEREXPRESSION; LONGEVITY; STABILITY;
Keywords:
DNA strand breaks; poly(ADP-ribose); DNA repair; genomic instability; cancer therapy; tumour cell resistance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Burkle, A Univ Newcastle Upon Tyne, Newcastle Gen Hosp, Wolfson Res Ctr, IHE,Inst Hlth Elderly,Dept Gerontol, Westgate Rd, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Univ Newcastle Upon Tyne Westgate Rd Newcastle UponTyne Tyne & Wear England NE4 6BE
Citazione:
A. Burkle, "Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability", CANCER LETT, 163(1), 2001, pp. 1-5

Abstract

Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is an immediate cellular reaction to DNA strand breakage as induced by alkylating agents, ionizing radiation or oxidants. The resulting formation of protein-coupled poly(ADP-ribose) facilitates survival of proliferating cells under conditions of DNA damage, probably via its contribution to DNA base-excision repair. Furthermore, based on recent results there is a role emerging for PARP-1 as a negative regulator of genomic instability in cells under genotoxic stress. Regarding possible applications for clinical cancer therapy with DNA-damaging agents, it appears that both inhibition and up-regulation of the poly(ADP-ribosyl)ation response in the malignant cells to be eradicated are promising strategies to improve the outcome of such therapy, albeit for different reasons. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:23:52