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Titolo:
Antitumor activity of tributyrin in murine melanoma model
Autore:
Giermasz, A; Nowis, D; Jalili, A; Basak, G; Marczak, M; Makowski, M; Czajka, A; Mlynarczuk, I; Hoser, G; Stok, T; Lewandowski, S; Jakobisiak, M;
Indirizzi:
Med Univ Warsaw, Ctr Biostruct, Dept Immunol, PL-02004 Warsaw, Poland Med Univ Warsaw Warsaw Poland PL-02004 Immunol, PL-02004 Warsaw, Poland Med Univ Warsaw, Ctr Biostruct, Dept Histol & Embriol, Warsaw, Poland Med Univ Warsaw Warsaw Poland ct, Dept Histol & Embriol, Warsaw, Poland Med Univ Warsaw, Dept Dermatol, Warsaw, Poland Med Univ Warsaw Warsaw Poland niv Warsaw, Dept Dermatol, Warsaw, Poland Postgrad Ctr Med Study, Dept Clin Cytol, Warsaw, Poland Postgrad Ctr Med Study Warsaw Poland y, Dept Clin Cytol, Warsaw, Poland Cent Clin Hosp, Mil Sch Med, Oncol Clin, Warsaw, Poland Cent Clin Hosp Warsaw Poland p, Mil Sch Med, Oncol Clin, Warsaw, Poland
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 164, anno: 2001,
pagine: 143 - 148
SICI:
0304-3835(20010326)164:2<143:AAOTIM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-CELL LINES; SODIUM-BUTYRATE; CARCINOMA CELLS; PHASE-I; CANCER; APOPTOSIS; ACID; ARREST; MICE; POTENTIATION;
Keywords:
tributyrin; butyrate; melanoma; mouse; tumor therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Jakobisiak, M Med Univ Warsaw, Ctr Biostruct, Dept Immunol, Ul Chalubinskiego 5, PL-02004 Warsaw, Poland Med Univ Warsaw Ul Chalubinskiego 5 Warsaw Poland PL-02004
Citazione:
A. Giermasz et al., "Antitumor activity of tributyrin in murine melanoma model", CANCER LETT, 164(2), 2001, pp. 143-148

Abstract

Butyric acid has been known to inhibit growth and to induce differentiation of a variety of tumor cells. Butyrate-treated tumor cells have also been observed to undergo apoptosis. Although butyrate compounds have demonstrated antitumor activity in murine tumor models and have already been admitted to clinical trials in tumor patients, the exact mechanism of their antitumor effects has not been elucidated. The results of our study showed antitumor activity of tributyrin, a butyric acid prodrug, in murine melanoma model and are strongly suggestive that antiangiogenic effects could participate in antitumor effects of butyrate compounds in vivo. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:45:05