Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women
Autore:
Jernstrom, H; Deal, C; Wilkin, F; Chu, W; Tao, YZ; Majeed, N; Hudson, T; Narod, SA; Pollak, M;
Indirizzi:
McGill Univ, Jewish Gen Hosp, Dept Oncol, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 ncol, Montreal, PQ H3T 1E2, Canada Univ Toronto, Ctr Res Womens Hlth, Toronto, ON, Canada Univ Toronto Toronto ON Canada Ctr Res Womens Hlth, Toronto, ON, Canada Univ Lund Hosp, Dept Oncol, Jubileum Inst, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 , Jubileum Inst, S-22185 Lund, Sweden Univ Montreal, Dept Pediat, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 at, Montreal, PQ H3C 3J7, Canada Univ Montreal, St Justine Hosp, Montreal, PQ, Canada Univ Montreal Montreal PQ Canada , St Justine Hosp, Montreal, PQ, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Res Inst, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 Inst, Montreal, PQ H3T 1E2, Canada McGill Univ, Genome Ctr, Montreal, PQ, Canada McGill Univ Montreal PQ Canada ll Univ, Genome Ctr, Montreal, PQ, Canada
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 4, volume: 10, anno: 2001,
pagine: 377 - 384
SICI:
1055-9965(200104)10:4<377:GANFAW>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-MASS INDEX; IGF-I; SERUM LEVELS; CANCER RISK; PROSTATE-CANCER; FACTOR (IGF)-I; BREAST-CANCER; CHILDREN; IGFBP-1; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Pollak, M McGill Univ, Jewish Gen Hosp, Dept Oncol, 3755 Chemin Cote St Catherine, Montreal, PQ H3T 1E2, Canada McGill Univ 3755 Chemin Cote St Catherine Montreal PQ Canada H3T 1E2
Citazione:
H. Jernstrom et al., "Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women", CANC EPID B, 10(4), 2001, pp. 377-384

Abstract

Circulating levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein 3 (IGFBP-3) vary considerably between normal individuals, Recent epidemiological studies have provided evidence that these levels are predictive of risk of several common cancers. To evaluate possible sources of variation of the levels of circulating IGF-I and IGFBP-3in females, we studied specific candidate genetic and nongenetic factors in 311 nulliparous, premenopausal Caucasian women, 17-35 years of age. Womenwho used oral contraceptives (OC) had reduced levels of IGF-I (269 versus 301 ng/ml; P = 0.001 adjusted for age) and increased levels of IGFBP-3 (4213 versus 4009 ng/ml; P = 0.002, adjusted for age) compared with nonusers. The ratio of IGF-I:IGFBP-3 was associated with the dose of estrogen contained in the OC (P-trend = 0.006, adjusted for age). We identified a novel single bp polymorphism in the promoter region of the gene encoding IGFBP-3. This polymorphism was related to the level of IGFBP-3 in the circulation. MeanIGFBP-3 levels were 4390, 4130, and 3840 ng/ml for the AA, AC, and CC genotypes, respectively (P-trend = 0.006, adjusted for age and OC use). We observed no effect of a recently described polymorphism in the promoter region of the gene encoding IGF-I on the plasma IGF-I level, but there was evidence for a modifying effect of this locus on the influence of OC on the IGF-I level. Our results support the view that circulating IGF-I levels and IGFBP-3 levels are complex traits and are influenced by a number of interacting genetic and nongenetic factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:30:46