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Titolo:
Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States
Autore:
Rodriguez, C; Patel, AV; Calle, EE; Jacobs, EJ; Chao, A; Thun, MJ;
Indirizzi:
Amer Canc Soc, Natl Home Off, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA Amer Canc Soc Atlanta GA USA 30329 urveillance Res, Atlanta, GA 30329 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 4, volume: 10, anno: 2001,
pagine: 345 - 353
SICI:
1055-9965(200104)10:4<345:BMIHAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; PHYSICAL-ACTIVITY; RELATIVE WEIGHT; BREAST-CANCER; NORWEGIAN MEN; COLON-CANCER; IGF-I; RISK; DIET; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez, C Amer Canc Soc, Natl Home Off, Dept Epidemiol & Surveillance Res, 1599 Clifton Rd NE, Atlanta, GA 30329 USA Amer Canc Soc 1599 Clifton RdNE Atlanta GA USA 30329 329 USA
Citazione:
C. Rodriguez et al., "Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States", CANC EPID B, 10(4), 2001, pp. 345-353

Abstract

Body weight and height have both been associated consistently with postmenopausal breast cancer but less consistently with prostate cancer. The present study examined the relationship between body mass index (BMI), height, and death from prostate cancer in two large American Cancer Society cohorts. Men in the study were selected from the male participants in Cancer Prevention Study I (CPS-I; enrolled in 1959 and followed through 1972) and CancerPrevention Study II (CPS-II; enrolled in 1982 and followed through 1996), After exclusions, 1,590 prostate cancer deaths remained among 381,638 men in CPS-I and 3,622 deaths among 434,630 men in CPS-II, Cox proportional hazards modeling was used to compute rate ratios (RR) and to adjust for confounders. Prostate cancer mortality rates were significantly higher among obese(BMI, greater than or equal to 30) than nonobese (BMI, <25) men in both cohorts [adjusted RR, 1.27; 95% confidence interval (CI), 1.04-1.56 in CPS-I;RR, 1.21; 95% CI, 1.07-1.37 in CPS-II], Prostate cancer mortality rates inthe CPS-I cohort were lowest for the shortest men (RR, 0.80; 95% CI, 0.63-1.03 for men <65 inches versus 65-66 inches) and highest for the tallest men (RR, 1.39; 95% CI, 1.11-1.74 for men greater than or equal to 73 inches tall versus 65-66 inches). Rates remained constant among men 65-72 inches tall. No association between height and prostate cancer mortality was observed in the CPS-II cohort (RR, 1.03; 95% CI, 0.82-1.29 for men greater than orequal to 75 versus 65-66 inches). These results support the hypothesis that obesity increases risk of prostate cancer mortality. Decreased survival among obese men may be a likely explanation for this association.

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Documento generato il 05/04/20 alle ore 02:07:44