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Titolo:
Effects of yohimbine on the antinociceptive and place conditioning effectsof opioid agonists in rodents
Autore:
Morales, L; Perez-Garcia, C; Alguacil, LF;
Indirizzi:
Univ San Pablo CEU, Pharmacol Lab, Madrid 28660, Spain Univ San Pablo CEUMadrid Spain 28660 Pharmacol Lab, Madrid 28660, Spain
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 133, anno: 2001,
pagine: 172 - 178
SICI:
0007-1188(200105)133:1<172:EOYOTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-WITHDRAWAL; KAPPA-AGONISTS; GUINEA-PIG; CLONIDINE; RATS; ANALGESIA; RECEPTORS; MICE; TOLERANCE; PREFERENCE;
Keywords:
Opioid; morphine; SNC80; U-50,488; yohimbine; antinociception; addiction; hot plate; tail-immersion; place conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Alguacil, LF Univ San Pablo CEU, Pharmacol Lab, POB 67, Madrid 28660, Spain Univ San Pablo CEU POB 67 Madrid Spain 28660 id 28660, Spain
Citazione:
L. Morales et al., "Effects of yohimbine on the antinociceptive and place conditioning effectsof opioid agonists in rodents", BR J PHARM, 133(1), 2001, pp. 172-178

Abstract

1 The pharmacological modulation of opioid actions by drugs acting on heterologous mechanisms could be useful to overcome some of the main problems associated with the use of opiate agonists. Based on previous findings on the interactions between yohimbine and opioid drugs, we have further studied the effects of yohimbine on the antinociceptive and positive-negative reinforcing effects of morphine (mu opioid receptor-preferring agonist), U-50,488 (kappa agonist) and SNC80 (delta agonist).2 Pretreatment with yohimbine completely blocked the antinociception provided by the three opioid agonists in the mouse tail-immersion test.3 A similar blockade of SNC80 and U-50,488-induced antinociception was observed with yohimbine in the mouse hot plate test at the same doses. In thisparadigm, the effect of the kappa agonist was very slight and the actions of yohimbine rather variable.4 In place conditioning experiments with SD (Sprague-Dawley) male rats, yohimbine alone was inactive but it limited the preference induced by morphine and SNC80 and the aversive effect of U-50,488. Impaired novelty preference was also observed with the combination of yohimbine and U-50,488.5 It is concluded that yohimbine tends to limit opioid antinociception andthe addictive potential of mu and delta opioid agonists. More selective drugs could help to understand the mechanisms involved in these actions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:24:53