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Titolo:
Inhibition of amygdaloid dopamine D-2 receptors impairs emotional learningmeasured with fear-potentiated startle
Autore:
Greba, Q; Gifkins, A; Kokkinidis, L;
Indirizzi:
Univ Canterbury, Dept Psychol, Christchurch 1, New Zealand Univ Canterbury Christchurch New Zealand 1 , Christchurch 1, New Zealand
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 899, anno: 2001,
pagine: 218 - 226
SICI:
0006-8993(20010427)899:1-2<218:IOADDR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; LONG-TERM POTENTIATION; ACOUSTIC STARTLE; SHOCK-SENSITIZATION; RAT-BRAIN; D2-DOPAMINE RECEPTORS; ANTAGONIST SCH-23390; BASOLATERAL AMYGDALA; TEMPORAL GRADIENT; CONDITIONAL FEAR;
Keywords:
fear-potentiated startle; amygdala; D-2 dopamine receptor; raclopride; shock sensitization; shock reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kokkinidis, L Univ Canterbury, Dept Psychol, Private Bag 4800, Christchurch 1, New Zealand Univ Canterbury Private Bag 4800 Christchurch New Zealand1
Citazione:
Q. Greba et al., "Inhibition of amygdaloid dopamine D-2 receptors impairs emotional learningmeasured with fear-potentiated startle", BRAIN RES, 899(1-2), 2001, pp. 218-226

Abstract

Considerable advances have been made in understanding the neurocircuitry underlying the acquisition and expression of Pavlovian conditioned fear responses. Within the complex cellular and molecular processes mediating fearfulness, amygdaloid dopamine (DA), originating from cells in the ventral tegmental area (VTA) of the midbrain, is thought to contribute to fear-motivated responding. Considering that blockade of DA D-2 receptors is a common mechanism of action for antipsychotic agents, eve hypothesized that inhibitionof D-2 receptors in the amygdala may be involved in the antiparanoid effects of these drugs. To assess the role of amygdaloid DA D-2 receptors in aversive emotionality, the D-2 receptor antagonist raclopride was infused intothe amygdala prior to Pavlovian fear conditioning. Potentiated startle wasused as a behavioral indicator of fear and anxiety. Classical fear conditioning and acoustic startle testing were conducted in a single session allowing for the concomitant assessment of shock reactivity with startle enhancement. Depending on dose, the results found conditioned fear acquisition andretention to be impaired following administration of raclopride into the amygdala. Additionally, the learning deficit was dissociated from shock detection and from fear expression assessed with the shock sensitization of acoustic startle. These findings further refine the known neural mechanisms ofamygdala-based emotional learning and memory and were interpreted to suggest that, along with D-1 receptors, D-2 receptors in the amygdala may mediate the formation and the retention of newly-acquired fear associations. (C) 2001 Elsevier science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:01:07