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Titolo:
Perineuronal nets in the rat medial nucleus of the trapezoid body surroundneurons immunoreactive for various amino acids, calcium-binding proteins and the potassium channel subunit Kv3.1b
Autore:
Hartig, W; Singer, A; Grosche, J; Brauer, K; Ottersen, OP; Bruckner, G;
Indirizzi:
Univ Leipzig, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany Univ Leipzig Leipzig Germany D-04109 Brain Res, D-04109 Leipzig, Germany Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317 sic Med Sci, Dept Anat, N-0317 Oslo, Norway
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 899, anno: 2001,
pagine: 123 - 133
SICI:
0006-8993(20010427)899:1-2<123:PNITRM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; AUDITORY BRAIN-STEM; PARVALBUMIN-CONTAINING NEURONS; GAMMA-AMINOBUTYRIC ACID; LECTIN VICIA-VILLOSA; CAT VISUAL-CORTEX; EXTRACELLULAR-MATRIX; GUINEA-PIG; GABAERGIC NEURONS; CEREBRAL-CORTEX;
Keywords:
extracellular matrix; chondroitin sulfate proteoglycan; glycine; glutamate; aspartate; parvalbumin; calbindin; triple fluorescence labeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Hartig, W Univ Leipzig, Paul Flechsig Inst Brain Res, Jahnallee 59, D-04109 Leipzig,Germany Univ Leipzig Jahnallee 59 Leipzig Germany D-04109 ipzig,Germany
Citazione:
W. Hartig et al., "Perineuronal nets in the rat medial nucleus of the trapezoid body surroundneurons immunoreactive for various amino acids, calcium-binding proteins and the potassium channel subunit Kv3.1b", BRAIN RES, 899(1-2), 2001, pp. 123-133

Abstract

Perineuronal nets (PNs) are known as chondroitin sulfate-rich, lattice-like coatings of the extracellular matrix ensheathing mainly GABAergic, parvalbumin-containing neurons especially in the cerebral cortex. PNs have also been detected around GABA-immunonegative cells which were shown to be not aminergic, cholinergic, nitrinergic or peptidergic in various brain regions of some mammalian species. To find out whether glycine and aspartate may occur in net-bearing neurons the present study was focused on the rat medial nucleus of the trapezoid body (MNTB) which contains a large portion of cellsimmunoreactive for these amino acids, but appears to be devoid of GABA-immunoreactive cell bodies. PNs were detected around many glycine- and aspartate-immunopositive neurons in the MNTB by carbocyanine double labeling and confocal laser scanning microscopy. An additional finding was that the lectin-cytochemically stained extracellular matrix surrounds the calretinin-immunoreactive calyces of Held known as giant glutamatergic endbulbs which cover glycinergic principal cells in the MNTB. As elucidated by triple fluorescence labeling. the vast majority of somata co-expressed the calcium-bindingproteins parvalbumin and calbindin, but not calretinin. The observed co-localization of PNs and immunoreactivity for the voltage-dependent potassium channel Kv3.lb - as an established marker of fast-firing parvalbumin-containing neurons - supports the assumed function of PNs as a cation exchanger ensuring rapid ion transport as required by highly active nerve cells. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:39:24