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Titolo:
Nicotine sensitization increases dendritic length and spine density in thenucleus accumbens and cingulate cortex
Autore:
Brown, RW; Kolb, B;
Indirizzi:
Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada Univ Lethbridge Lethbridge AB Canada T1K 3M4 thbridge, AB T1K 3M4, Canada
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 899, anno: 2001,
pagine: 94 - 100
SICI:
0006-8993(20010427)899:1-2<94:NSIDLA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION; FIBROBLAST-GROWTH-FACTOR; RAT-BRAIN; PREFRONTAL CORTEX; BINDING-SITES; CEREBRAL-CORTEX; ADDICTIVE DRUGS; UP-REGULATION; RECEPTOR; AMPHETAMINE;
Keywords:
nicotine; Golgi stain; sensitization; dendritic morphology; nucleus accumbens; cingulate cortex; parietal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, RW E Tennessee State Univ, Dept Psychol, Johnson City, TN 37614 USAE Tennessee State Univ Johnson City TN USA 37614 , TN 37614 USA
Citazione:
R.W. Brown e B. Kolb, "Nicotine sensitization increases dendritic length and spine density in thenucleus accumbens and cingulate cortex", BRAIN RES, 899(1-2), 2001, pp. 94-100

Abstract

This study investigated the effects of repeated administrations of nicotine (0.7 mg/kg) on dendritic morphology in the nucleus accumbens (NAcc), prefrontal cortex (Cg 3), and parietal cortex (Par 1). Animals were habituated for 3 days to a locomotor box, and after habituation, every second day for 5 weeks rats were placed into the locomotor chamber immediately after a subcutaneous injection of nicotine or saline. Rats demonstrated tolerance to an initial hypoactive response after each nicotine injection, and this was followed by an increase in activity after each injection (behavioral sensitization). This increase in activity was still present on a nicotine challenge after a 2-week abstinence period. One week after the nicotine challenge day, all rats were perfused and brains were removed. These brains we stainedusing Golgi-Cox procedures, and dendrites from the nucleus accumbens (N Ace), medial frontal cortex (Cg 3) and parietal cortex (Par 1) were analyzed using the camera lucida procedure. Results showed that rats receiving nicotine demonstrated an increase in dendritic length and spine density relativeto controls in the NAcc and Cg3 brain areas, but not Par 1. The increase observed in the NAcc was significantly greater than what has been found withamphetamine or cocaine, and possible underlying mechanisms were discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 03/07/20 alle ore 01:40:44