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Titolo:
Effect of novel stressors on gene expression of tyrosine hydroxylase and monoamine transporters in brainstem noradrenergic neurons of long-term repeatedly immobilized rats
Autore:
Rusnak, M; Kvetnansky, R; Jelokova, J; Palkovits, M;
Indirizzi:
Slovak Acad Sci, Inst Expt Endocrinol, Bratislava 83306, Slovakia Slovak Acad Sci Bratislava Slovakia 83306 ol, Bratislava 83306, Slovakia NINDS, Neurochem Lab, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 S, Neurochem Lab, NIH, Bethesda, MD 20892 USA NIMH, Genet Lab, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Genet Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 899, anno: 2001,
pagine: 20 - 35
SICI:
0006-8993(20010427)899:1-2<20:EONSOG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; INDUCED NOREPINEPHRINE RELEASE; STEM CATECHOLAMINERGIC GROUPS; ACUTE RESTRAINT STRESS; C-FOS EXPRESSION; LOCUS-COERULEUS; DOPAMINE TRANSPORTER; ADRENOCORTICAL AXIS;
Keywords:
tyrosine hydroxylase; norepinephrine transporter; vesicular monoamine transporter; gene expression; repeated stress; novel stressor; locus coeruleus; brainstem noradrenergic cell group;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Rusnak, M Slovak Acad Sci, Inst Expt Endocrinol, Bratislava 83306, Slovakia Slovak Acad Sci Bratislava Slovakia 83306 lava 83306, Slovakia
Citazione:
M. Rusnak et al., "Effect of novel stressors on gene expression of tyrosine hydroxylase and monoamine transporters in brainstem noradrenergic neurons of long-term repeatedly immobilized rats", BRAIN RES, 899(1-2), 2001, pp. 20-35

Abstract

Responses of central noradrenergic (NE) neurons to stressors like immobilization (IMO), cold exposure, insulin-induced hypoglycemia, and cellular glucoprivation caused by 2-deoxy-D-glucose (2-DG) were investigated in intact and long-term repeatedly immobilized (LTR, 2 h daily IMO for 41 days) rats. Expression of tyrosine hydroxylase (TH), norepinephrine transporter (NET) and vesicular monoamine transporter (VMAT2) genes were determined by using in situ hybridization histochemistry in brainstem A1, A2, A5 and locus coeruleus (LC) neurons. TH mRNA levels were increased by single IMO or 2-DG administration in all areas studied. Cold was effective only in LC and A2 neurons while insulin had no effect. LTR immobilization elevated TH mRNA levelsin all investigated cell groups. These elevations were equally high to those elicited by a single IMO in each noradrenergic group, except the LC where LTR IMO was less effective than the single IMO. The levels of NET and VMAT2 mRNAs were elevated only in the A1 and A2 cell groups of LTR IMO rats. Anewly applied IMO in LTR rats did not alter TH, NET, and VMAT2 mRNA levelsin any NE cell group investigated. Novel stressors like cold and 2-DG exaggerated the increased TH mRNA levels only in the LC of LTR IMO rats, unlikein the other NE cell groups. The present data indicate that repeated exposure of rats to homotypic stressor induces an adaptation of NE neurons, whereas single exposure of such animals to heterotypic novel stressor produces an exaggerated response of the system at the level of TH (in LC) and NET (in A1, A2) gene expression. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:53:31