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Titolo:
Hypoxic-ischemic injury of the perinatal brain and neuronal rescue
Autore:
Gunn, AJ; Guan, J; Bennet, L; Jones, KR; Gluckman, PD;
Indirizzi:
Univ Auckland, Res Ctr Dev Med & Biol, Dept Pediat, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 ept Pediat, Auckland 1, New Zealand
Titolo Testata:
BRAIN HYPOXIA AND ISCHEMIA
, volume: 24, anno: 2000,
pagine: 41 - 57
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; UMBILICAL-CORD OCCLUSION; MAGNETIC-RESONANCE SPECTROSCOPY; CENTRAL-NERVOUS-SYSTEM; N-TERMINAL TRIPEPTIDE; DEVELOPING RAT-BRAIN; CELL-DEATH; FETAL SHEEP; IGF-I; INFANT RAT;
Keywords:
hypoxia; ischemia; apoptosis; necrosis; growth factor; neuronal rescue;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Gunn, AJ Univ Auckland, Res Ctr Dev Med & Biol, Dept Pediat, Private Bag 92019, Auckland 1, New Zealand Univ Auckland Private Bag 92019 Auckland NewZealand 1 w Zealand
Citazione:
A.J. Gunn et al., "Hypoxic-ischemic injury of the perinatal brain and neuronal rescue", RES LEG MED, 24, 2000, pp. 41-57

Abstract

Exposure to perinatal asphyxia remains a significant cause of death and long-term neurological disability. Studies of asphyxia have demonstrated thatthe development of hypotension and consequent hypotension during ring asphyxia, i.e. hypoxia-ischemia, plays a central role in localising and precipitating neural injury. Functional models of hypoxia-ischemia have therefore been used to characterise the events surrounding asphyxial injury. The seminal observation from both clinical and experimental studies is that brain cells may initially, recover from the primary hypoxic-ischemic event, only to die many hours, or even days later (secondary or delayed cell death). We have found that the evolution of hypoxic-ischemic injury is associated withthe characteristic induction over time of a number of broadly anti-apoptotic growth factors including insulin like growth factor 1 (IGF-1). Secondarycell death appears to be due to the induction of 'apoptosis'-like events involving a pre-programmed cell death cascade; thus growth factor induction may help limit the development of cell death. Consistent with this hypothesis, exogenous therapy with IGF-1 and similar agents within a few hours of injury has been shown to be neuroprotective. It is likely, that clinically effective rescue therapies in the future will require the development of a multi-modal approach, which includes anti-apoptotic agents such as IGF-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:01:37