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Titolo:
Involvement of intracellular Ca2+ in the regulation of bovine leukemia virus expression
Autore:
Bondzio, A; Abraham-Podgornik, A; Blankenstein, P; Risse, S;
Indirizzi:
Free Univ Berlin, Dept Vet Biochem, D-14163 Berlin, Germany Free Univ Berlin Berlin Germany D-14163 Biochem, D-14163 Berlin, Germany Free Univ Berlin, Dept Vet Virol, D-10117 Berlin, Germany Free Univ Berlin Berlin Germany D-10117 t Virol, D-10117 Berlin, Germany
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 3, volume: 382, anno: 2001,
pagine: 407 - 416
SICI:
1431-6730(200103)382:3<407:IOICIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NF-KAPPA-B; LONG TERMINAL REPEAT; SIGNAL-TRANSDUCTION PATHWAYS; TRANSCRIPTION FACTORS; POTENT INHIBITORS; BINDING PROTEIN; PHORBOL ESTER; IN-VIVO; ACTIVATION;
Keywords:
antioxidants; BLV antigen; Ca2+ ionophore; mobility shift assays; NF-kappa B; PKC inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bondzio, A Free Univ Berlin, Dept Vet Biochem, Oertzenweg 19B, D-14163 Berlin, Germany Free Univ Berlin Oertzenweg 19B Berlin Germany D-14163 Germany
Citazione:
A. Bondzio et al., "Involvement of intracellular Ca2+ in the regulation of bovine leukemia virus expression", BIOL CHEM, 382(3), 2001, pp. 407-416

Abstract

The calcium ionophore A23187, which was used to increase the intracellularcalcium concentration ([Ca2+]), was analyzed for effects on bovine leukemia virus (BLV) expression in two BLV infected cell lines. To clarify the role of intracellular free calcium in this response, [Ca2+] was measured during ionophore treatment with the fluorescent calcium indicator Fura-2. Elevation of intracellular calcium under these conditions caused an enhancement of BLV gp51 and p24 synthesis as well as an activation of the BLV long terminal repeat (LTR) in a dose-dependent manner. Furthermore, it was observed that elevated levels of intracellular calcium following A23187 stimulation lead to activation of NF-KB. Based on inhibitor studies, we hypothesize thatthe effect of A23187 on BLV expression appears to be mediated by PKC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:52:07