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Titolo:
A comparative pharmacodynamic study of the arrhythmogenicity of antidepressants, fluvoxamine and imipramine, in guinea pigs
Autore:
Ohtani, H; Odagiri, Y; Sato, H; Sawada, Y; Iga, T;
Indirizzi:
Tokyo Univ Hosp, Dept Pharm, Bunkyo Ku, Tokyo 1138655, Japan Tokyo Univ Hosp Tokyo Japan 1138655 arm, Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 5, volume: 24, anno: 2001,
pagine: 550 - 554
SICI:
0918-6158(200105)24:5<550:ACPSOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-DEPRESSANTS; DE-POINTES; RATS; PHARMACOKINETICS; TERFENADINE; DESIPRAMINE; METABOLISM; RABBITS;
Keywords:
imipramine; fluvoxamine; QT interval; arrhythmia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ohtani, H Tokyo Univ Hosp, Dept Pharm, Bunkyo Ku, Tokyo 1138655, Japan Tokyo Univ Hosp Tokyo Japan 1138655 o Ku, Tokyo 1138655, Japan
Citazione:
H. Ohtani et al., "A comparative pharmacodynamic study of the arrhythmogenicity of antidepressants, fluvoxamine and imipramine, in guinea pigs", BIOL PHAR B, 24(5), 2001, pp. 550-554

Abstract

Among several classes of antidepressants, tricyclic antidepressants are known to prolong QTe intervals (QT interval corrected by heart rate) in electrocardiograms, while selective serotonin uptake inhibitors (SSRI) are considered to be devoid of arrhythmogenicity, In this study, H e aimed to compare the arrhythmogenic potencies of imipramine (IMI), a typical tricyclic antidepressant, and fluvoxamine (FLV), an SSRI, at therapeutic and supratherapeutic concentrations using guinea pigs in vivo. Guinea pigs were anesthetized, and IMI (10 and 20 mg/kg/h) or FLV (20 mg/kg/h) was intravenously administered for 90 minutes to obtain the time-courses of drug concentrations in plasma and thr changes in thp QTc intervals during and after the drug administration,IMI induced distinct QTe prolongation in a dose-dependent manner, while FLV prolonged QTe intervals only; slightly, A pharmacokinetic-pharmacodynamicanalysis revealed that the potency for QTc prolongation of IMI was 1.7-fold higher than that of FLV Taking the therapeutic concentration into account, the clinical risk of FLV for QTc prolongation was suggested to be 5-fold lower than that of IMI, Therefore, this SSRI agent was suggested to be safer than the tricyclic antidepressant for patients with cardiac risk factors,including arrhythmia, or for those taking other arrhythmogenic drugs concomitantly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:03:23