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Titolo:
Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructusby human intestinal bacteria and its relation to some biological activities
Autore:
Bae, EA; Yook, CS; Oh, OJ; Chang, SY; Nohara, T; Kim, DH;
Indirizzi:
Kyung Hee Univ, Coll Pharm, Dongdaemun Ku, Seoul 130701, South Korea KyungHee Univ Seoul South Korea 130701 un Ku, Seoul 130701, South Korea Sookmyung Womens Univ, Coll Pharm, Yongsan Ku, Seoul 140742, South Korea Sookmyung Womens Univ Seoul South Korea 140742 Seoul 140742, South Korea Korea Food & Drug Adm, Eunpyung Ku, Seoul 122704, South Korea Korea Food &Drug Adm Seoul South Korea 122704 Seoul 122704, South Korea Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan Kumamoto Univ Kumamoto Japan 8620973 maceut Sci, Kumamoto 8620973, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 5, volume: 24, anno: 2001,
pagine: 582 - 585
SICI:
0918-6158(200105)24:5<582:MOCFAD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONOIDS; ACID;
Keywords:
Acanthopanax divaricatus var. albeofructus; chiisanoside; human intestinal bacteria; biological activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DH Kyung Hee Univ, Coll Pharm, Dongdaemun Ku, 1 Hoegi, Seoul 130701, South Korea Kyung Hee Univ 1 Hoegi Seoul South Korea 130701 0701, South Korea
Citazione:
E.A. Bae et al., "Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructusby human intestinal bacteria and its relation to some biological activities", BIOL PHAR B, 24(5), 2001, pp. 582-585

Abstract

The metabolic pathway of chiisanoside isolated from leaves of Acanthopanaxdivaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when chiisanoside were incubated for 15h with human intestinal bacteria. This metabolic pathway proceeded more potently,with the protein fraction than with human intestinal bacteria. The irt vitro cytotoxicity of chiisanogenin was superior to that of chiisanoside, H+/H+ ATPase was more potently inhibited by chiisanogenin than by chiisanoside, However, the anti-rotaviral activity of chiisanoside was more potent than that of chiisanogenin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:05:22