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Titolo:
Hypocretin/orexin, sleep and narcolepsy
Autore:
Hungs, M; Mignot, E;
Indirizzi:
Stanford Univ, Med Ctr, Stanford Ctr Narcolepsy, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA
Titolo Testata:
BIOESSAYS
fascicolo: 5, volume: 23, anno: 2001,
pagine: 397 - 408
SICI:
0265-9247(200105)23:5<397:HSAN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL HYPOTHALAMIC AREA; RECEPTOR MESSENGER-RNA; ADULT-RAT BRAIN; OREXIN-A; FOOD-INTAKE; CANINE NARCOLEPSY; BODY-WEIGHT; SPINAL-CORD; DIFFERENTIAL DISTRIBUTION; LUTEINIZING-HORMONE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Mignot, E Stanford Univ, Med Ctr, Stanford Ctr Narcolepsy, Dept Psychiat &Behav Sci, 1201 Welch Rd,P-114, Stanford, CA 94305 USA Stanford Univ 1201 Welch Rd,P-114 Stanford CA USA 94305 4305 USA
Citazione:
M. Hungs e E. Mignot, "Hypocretin/orexin, sleep and narcolepsy", BIOESSAYS, 23(5), 2001, pp. 397-408

Abstract

The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy and unusually rapid transitions to rapid-eye-movement sleep, opens a new field of investigation inthe area of sleep control physiology, Hypocretin-1 and -2 (also called orexin-A and -B) are newly discovered neuropeptides processed from a common precursor, preprohypocretin, Hypocretin-containing cells are located exclusively in the lateral hypothalamus, with widespread projections to the entire neuroaxis. Two known receptors, Hcrtr1 and Hcrtr2, have been reported. The functional significance of the hypocretin system is rapidly emerging in both animals and humans. Hypocretin abnormalities cause narcolepsy in dogs, human and mice. The role of the hypocretin system in normal sleep regulation is more uncertain. We believe hypocretin cells drive cholinergic and monoaminergic activity across the sleep cycle. Input from the suprachiasmatic nucleus to hypocretin-containing neurons may explain the occurrence of clock-dependent alertness. Other functions are suggested by pharmacological and neurochemical experiments. These include regulation of food intake, neuroendocrine function, autonomic nervous system activity and energy balance. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 02:22:33