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Titolo:
Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor
Autore:
Munday, J; Kerr, S; Ni, J; Cornish, AL; Zhang, JQ; Nicoll, G; Floyd, H; Mattei, MG; Moore, P; Liu, D; Crocker, PR;
Indirizzi:
Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, ScotlandUniv Dundee Dundee Scotland DD1 5EH ust Bioctr, Dundee DD1 5EH, Scotland Human Genome Sci Inc, Rockville, MD 20850 USA Human Genome Sci Inc Rockville MD USA 20850 Inc, Rockville, MD 20850 USA Fac Med Marseille, Unite Genet Med & Dev, INSERM U491, F-13385 Marseille, France Fac Med Marseille Marseille France F-13385 91, F-13385 Marseille, France
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 355, anno: 2001,
parte:, 2
pagine: 489 - 497
SICI:
0264-6021(20010415)355:<489:ICALEO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN-ASSOCIATED GLYCOPROTEIN; NATURAL-KILLER-CELLS; IMMUNOGLOBULIN SUPERFAMILY; INHIBITORY RECEPTOR; MOLECULAR-CLONING; SIALOADHESIN FAMILY; MYELOID CELLS; CD22; CD33; MEMBER;
Keywords:
immunoglobulin superfamily; inhibitory receptor; innate immunity; lectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Crocker, PR Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH Dundee DD1 5EH, Scotland
Citazione:
J. Munday et al., "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor", BIOCHEM J, 355, 2001, pp. 489-497

Abstract

Here we characterize Siglec-10 as a new member of the Siglec family of sialic acid-binding Ig-like lectins, A full-length cDNA was isolated from a human spleen library and the corresponding gene identified. Siglec-10 is predicted to contain five extracellular Ig-like domains and a cytoplasmic tail containing three putative tyrosine-based signalling motifs. Siglec-10 exhibited a high degree of sequence similarity to CD33-related Siglecs and mapped to the same region, on chromosome 19q13,3. The expressed protein was ableto mediate sialic acid-dependent binding to human erythrocytes and solublesialoglycoconjugates. Using specific antibodies, Siglec-10 was detected onsubsets of human leucocytes including eosinophils, monocytes and a minor population of natural killer-like cells. The molecular properties and expression pattern suggest that Siglec-10 may function as an inhibitory receptor within the innate immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:11:53