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Titolo:
Molecular genetic identification of a candidate receptor gene for sweet taste
Autore:
Kitagawa, M; Kusakabe, Y; Miura, H; Ninomiya, Y; Hino, A;
Indirizzi:
Minist Agr Forest & Fisheries, Natl Food Res Inst, Mol Engn Lab, Tsukuba, Ibaraki 3058642, Japan Minist Agr Forest & Fisheries Tsukuba Ibaraki Japan3058642 058642, Japan Biooriented Technol Res Advancement Inst, Oomiya, Saitama 3310044, Japan Biooriented Technol Res Advancement Inst Oomiya Saitama Japan 3310044 pan Kyushu Univ, Grad Sch Dent Sci, Sect Oral Neurosci, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ci, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 283, anno: 2001,
pagine: 236 - 242
SICI:
0006-291X(20010427)283:1<236:MGIOAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE-RECEPTOR; PUTATIVE PHEROMONE RECEPTORS; TRANSDUCTION; FAMILY; MAMMALS; BITTER; CELLS; MICE;
Keywords:
taste receptor; taste papillae; taste bud; G protein-coupled receptor; seven transmembrane receptor; cloning; in situ hybridization; radiation hybrid mapping; saccharin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kitagawa, M Minist Agr Forest & Fisheries, Natl Food Res Inst, Mol Engn Lab, 2-1-12 Kannondai, Tsukuba, Ibaraki 3058642, Japan Minist Agr Forest & Fisheries 2-1-12 Kannondai Tsukuba Ibaraki Japan 3058642
Citazione:
M. Kitagawa et al., "Molecular genetic identification of a candidate receptor gene for sweet taste", BIOC BIOP R, 283(1), 2001, pp. 236-242

Abstract

A cDNA clone encoding a novel member of the putative taste receptor T1R family, designated T1R3, was isolated from circumvallate papillae of the mouse tongue using degenerate primers. Reverse transcription-polymerase chain reaction analysis showed predominant expression of the receptor in circumvallate papillae. In situ hybridization analysis revealed that T1R3 was expressed in a subset of taste receptor cells in taste buds and that the topographic distribution of T1R3 in various taste papillae was different from thoseof the other T1R members. Genetic mapping of T1R3 with a mouse/hamster radiation hybrid panel located the gene on the distal end of mouse chromosome 4 correlated with the Sac locus affecting sweet sensitivity of mice. Our results indicate that T1R3 may serve as the receptor for sweet perception in mice. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:57:45