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Titolo:
1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression
Autore:
Gaschott, T; Wachtershauser, A; Steinhilber, D; Stein, J;
Indirizzi:
Univ Frankfurt, Dept Med 2, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 Med 2, D-6000 Frankfurt, Germany Univ Frankfurt, Inst Pharmaceut Chem, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 Chem, D-6000 Frankfurt, Germany
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 283, anno: 2001,
pagine: 80 - 85
SICI:
0006-291X(20010427)283:1<80:1EBPE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELL DIFFERENTIATION; COLON-CARCINOMA-CELLS; KINASE INHIBITOR P27; GROWTH-FACTOR-BETA; VITAMIN-D-RECEPTOR; SODIUM-BUTYRATE; LEUKEMIA-CELLS; CANCER CELLS; CACO-2 CELLS; IN-VITRO;
Keywords:
butyrate; Caco-2 cells; differentiation; 1,25-dihydroxycholecalciferol; p21(Waf1/Cip1); p27(Kip1); tributyrin; vitamin D receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, J Univ Frankfurt, Dept Internal Med 2, Div Gastroenterol & Clin Nutr, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 any
Citazione:
T. Gaschott et al., "1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression", BIOC BIOP R, 283(1), 2001, pp. 80-85

Abstract

Butyrate, a short-chain fatty acid produced in the colon, as well as its prodrug tributyrin, reduce proliferation and increase differentiation of colon cancer cells, p21(Waf1/CiP1) and p27(Kip1) are negative regulators of cell cycle and are thought to have a key function in the differentiation of various cell lines. We studied the effects of butyrate on differentiation, VDR expression, as well as on p21(Waf1/CiP1) and p27(Kip1) expression in human colon cancer cells (Caco-2). Butyrate induced cell differentiation, which was further enhanced after addition of 1,25-dihydroxycholecalciferol. Synergistic effect of butyrate and dihydroxycholecalciferol in Caco-2 cells was due to butyrate-induced overexpression of VDR. While butyrate as well as dihydroxycholecalciferol increased p21(Waf1/Cip1) and p27(Kip1) expression,in contrast combined exposure of butyrate and dihydroxycholecalciferol resulted in a synergistic amplification of p21(Waf1/Cip1), but not of p27(Kip1) expression. These data imply that butyrate selectively increases p21(Waf1/Cip1) expression via upregulation of VDR in Caco-2 cells. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:11:58