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Titolo:
Reduced adhesion of monocyte-derived macrophages from CD36-deficient patients to type I collagen
Autore:
Janabi, M; Yamashita, S; Hirano, K; Matsumoto, K; Sakai, N; Hiraoka, H; Kashiwagi, H; Tomiyama, Y; Nozaki, S; Matsuzawa, Y;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Mol Sci, Suita, Osaka 5650871, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 283, anno: 2001,
pagine: 26 - 30
SICI:
0006-291X(20010427)283:1<26:RAOMMF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE GLYCOPROTEIN-IV; NF-KAPPA-B; CD36 DEFICIENCY; NAKA PLATELETS; GPIV CD36; RECEPTOR; ATHEROSCLEROSIS; IDENTIFICATION; TRANSFUSION; ACTIVATION;
Keywords:
monocyte-derived macrophages; CD36 deficiency; type I collagen; cell adhesion; receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yamashita, S Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 871, Japan
Citazione:
M. Janabi et al., "Reduced adhesion of monocyte-derived macrophages from CD36-deficient patients to type I collagen", BIOC BIOP R, 283(1), 2001, pp. 26-30

Abstract

CD36 is an 88-kDa glycoprotein expressed on platelets and monocyte/macrophages (M phi). CD36 is a multifunctional receptor for collagen, thrombospondin, oxidized low density lipoproteins (LDL), and long-chain fatty acids. The present study was performed to investigate whether CD36 can function as an adhesion molecule which is involved in mediating human macrophages (M phi) adhesion to type I collagen in vitro. The M phi of human CD36-deficient as well as normal control subjects were isolated and cultured on the multi-well plates coated with type I collagen, a natural ligand for CD36. Up to 2 h of incubation, the M phi from CD36-deficient patients showed almost a similar to 55% decrease in adhesion to type I collagen in comparison to those from controls (P < 0.01). However, there was no significant difference in the adhesion thereafter. Furthermore, the addition of antibody against CD36 into the media of control M<phi> significantly inhibited the adhesion by similar to 50% (P < 0.05). The addition of oxidized LDL (OxLDL) did not alteradhesion of M<phi> from both CD36-deficient and controls. These data suggest that CD36 is involved in the adhesion of M phi to type I collagen, especially in the early stage of adhesion. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:45:10