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Titolo:
Molecular and cellular biology of pre-malignancy in the gastrointestinal tract
Autore:
Jass, JR; Talbot, IC;
Indirizzi:
Univ Queensland, Mayne Med Sch, Dept Pathol, Herston, Qld 4006, Australia Univ Queensland Herston Qld Australia 4006 , Herston, Qld 4006, Australia
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 175 - 189
SICI:
1521-6918(200104)15:2<175:MACBOP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; ADENOMA-CARCINOMA SEQUENCE; ISLAND METHYLATOR PHENOTYPE; ABERRANT CRYPT FOCI; KI-RAS MUTATIONS; MICROSATELLITE INSTABILITY; P53 IMMUNOHISTOCHEMISTRY; NEOPLASTIC PROGRESSION; HYPERPLASTIC POLYPS; GENETIC ALTERATIONS;
Keywords:
genetic instability; methylation; oncogenes; tumour suppressor genes; adenoma; dysplasia; polyposis; colorectum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Jass, JR Univ Queensland, Mayne Med Sch, Dept Pathol, Herston Rd, Herston,Qld 4006, Australia Univ Queensland Herston Rd Herston Qld Australia 4006 , Australia
Citazione:
J.R. Jass e I.C. Talbot, "Molecular and cellular biology of pre-malignancy in the gastrointestinal tract", BEST PR RES, 15(2), 2001, pp. 175-189

Abstract

Important pathogenic alterations within established cancers are acquired during the premalignant stage. These genetic alterations can be grouped intospecific neoplastic pathways that differ within and between anatomical sites. By understanding the mechanisms that determine the initiation and progression of each pathway, it will be possible to develop novel approaches to the diagnosis, prevention and treatment of cancer. This chapter outlines the principles underlying the molecular characterization of pre-malignant lesions, taking colorectal neoplasia as the main model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:46:12