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Titolo:
Estrogenic potency of benzophenone and its metabolites in juvenile female rats
Autore:
Nakagawa, Y; Tayama, K;
Indirizzi:
Tokyo Metropolitan Res Lab Publ Hlth, Dept Toxicol, Shinjuku Ku, Tokyo 1690073, Japan Tokyo Metropolitan Res Lab Publ Hlth Tokyo Japan 1690073 1690073, Japan
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 2, volume: 75, anno: 2001,
pagine: 74 - 79
SICI:
0340-5761(200104)75:2<74:EPOBAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BISPHENOL-A; METHOXYCHLOR; OCTYLPHENOL; LIVER;
Keywords:
benzophenone; metabolites; uterotrophic assay; competitive binding assay; female rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, Y Tokyo Metropolitan Res Lab Publ Hlth, Dept Toxicol, Shinjuku Ku, 3-24-1 Hyakunin Cho, Tokyo 1690073, Japan Tokyo Metropolitan Res Lab Publ Hlth 3-24-1 Hyakunin Cho Tokyo Japan 1690073
Citazione:
Y. Nakagawa e K. Tayama, "Estrogenic potency of benzophenone and its metabolites in juvenile female rats", ARCH TOXIC, 75(2), 2001, pp. 74-79

Abstract

The estrogenic activity of benzophenone and its metabolites, benzhydrol and p-hvdroxybenzophenone, were investigated in vitro by estrogen receptor (ER) competitive ligand binding assay and in vivo by uterotrophic assay in juvenile female Spraeue-Dawley (SD) rats. p-Hydroxybenzophenone as well as diethylstilbestrol and bisphenol A, known xeno-estrogenic compounds, competedwith fluorescein-labeled 17 beta -estradiol to bind human recombinant ER alpha in a concentration-dependent manner. Fifty percent inhibitory values (ICU) of diethylstilbestrol, bisphenol A, and p-hydroxybenzophenone were approximately 10(-8), 100(-5), and 5x10(-5) M, respectively. However, neither the parent compound nor benzhydrol at concentrations from 10(-9) to 5x10(-4) M impaired the binding of 17 beta -estradiol to ER alpha. Juvenile femalerats (21-days-old) were given s.c. injections of benzophenone, its metabolites, and 17 beta -estradiol for 3 days. Administration of p-hydroxybenzosphenone (100-100 mg/kg) elicited an increase in absolute and relative uterine weights in a dose-dependent manner and 17 beta -estradiol (10 mug/kg) increased uterine weight approximately fourfold relative to control. The uterine response caused by both compounds was accompanied by an increase in luminal epithelial height and stromal cells in the uterus and an increase in thickness of vaginal epithelial cell layers with cornification. In contrast. benzophenone and benzhydrol at a dose of 400 mg/kg affected neither uterineweight nor histological changes of the uterus and vagina. These results indicate that p-hydroxybenzophenone, a metabolite of benzophenone, exhibits intrinsic xeno-estrogenic activity in the female reproductive tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 17:22:19