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Titolo:
Genetic variations and polymorphisms of G protein-coupled receptors: Functional and therapeutic implications
Autore:
Rana, BK; Shiina, T; Insel, PA;
Indirizzi:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 rmacol, La Jolla, CA 92093 USA
Titolo Testata:
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
, volume: 41, anno: 2001,
pagine: 593 - 624
SICI:
0362-1642(2001)41:<593:GVAPOG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-SENSING RECEPTOR; DOPAMINE D2 RECEPTOR; NEPHROGENIC DIABETES-INSIPIDUS; DOMINANT RETINITIS-PIGMENTOSA; BETA(2) ADRENERGIC-RECEPTOR; MUSCARINIC ACETYLCHOLINE-RECEPTOR; V2 VASOPRESSIN RECEPTOR; CELL-SURFACE EXPRESSION; 3RD INTRACELLULAR LOOP; DELTA-OPIOID RECEPTOR;
Keywords:
SNPs; variants; mutants; structure-function; complex diseases;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Rana, BK Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA UnivCalif San Diego La Jolla CA USA 92093 a Jolla, CA 92093 USA
Citazione:
B.K. Rana et al., "Genetic variations and polymorphisms of G protein-coupled receptors: Functional and therapeutic implications", ANN R PHARM, 41, 2001, pp. 593-624

Abstract

G protein-coupled receptors (GPCRs) represent a major class of proteins inthe genome of many species, including humans. In addition to the mapping of a number of human disorders to regions of the genome containing GPCRs, a growing body of literature has documented frequently occurring variations (i.e. polymorphisms) in GPCR loci. In this article, we use a domain-based approach to systematically examine examples of genetic variation in the coding and noncoding regions of GPCR loci. Data to date indicate that residues in GPCRs are involved in ligand binding and coupling to G proteins and that regulation can be altered by polymorphisms. Studies of GPCR polymorphisms have also uncovered the functional importance of residues not previously implicated from other approaches that are involved in the function of GPCRs. We predict that studies of GPCR polymorphisms will have a significant impacton medicine and pharmacology, in particular, by providing new means to subclassify patients in terms of both diagnosis and treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:43:58