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Titolo:
Interindividual variability in inhibition and induction of cytochrome P450enzymes
Autore:
Lin, JH; Lu, AYH;
Indirizzi:
Merck Res Labs, Dept Drug Metab, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486 ept Drug Metab, W Point, PA 19486 USA Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Lab, Piscataway, NJ 08854 USA
Titolo Testata:
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
, volume: 41, anno: 2001,
pagine: 535 - 567
SICI:
0362-1642(2001)41:<535:IVIIAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-METABOLIZING-ENZYMES; FIRST-PASS METABOLISM; HUMAN HEPATOCYTE CULTURES; HIV PROTEASE INHIBITOR; CHARCOAL-BROILED BEEF; GUT WALL METABOLISM; HUMAN-LIVER; GRAPEFRUIT JUICE; IN-VIVO; EXTRAHEPATIC TISSUES;
Keywords:
quantitative prediction of drug interactions; intestinal first-pass metabolism; genetic polymorphism; drug interactions;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, JH Merck Res Labs, Dept Drug Metab, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486 Metab, W Point, PA 19486 USA
Citazione:
J.H. Lin e A.Y.H. Lu, "Interindividual variability in inhibition and induction of cytochrome P450enzymes", ANN R PHARM, 41, 2001, pp. 535-567

Abstract

Drug interactions have always been a major concern in medicine for clinicians and patients. Inhibition and induction of cytochrome P450 (CYP) enzymesare probably the most common causes for documented drug interactions. Today, many pharmaceutical companies are predicting potential interactions of new drug candidates. Can in vivo drug interactions be predicted accurately from in vitro metabolic studies? Should the prediction be qualitative or quantitative? Although some scientists believe that quantitative prediction ofdrug interactions is possible, others are less optimistic and believe thatquantitative prediction would be very difficult. There are many factors that contribute to our inability to quantitatively predict drug interactions. One of the major complicating factors is the large interindividual variability in response to enzyme inhibition and induction. This review examines the sources that are responsible for the interindividual variability in inhibition and induction of cytochrome P450 enzymes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 04:52:49