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Titolo:
Cellular responses to DNA damage
Autore:
Norbury, CJ; Hickson, ID;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund Labs, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS es Fund Labs, Oxford OX3 9DS, England
Titolo Testata:
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
, volume: 41, anno: 2001,
pagine: 367 - 401
SICI:
0362-1642(2001)41:<367:CRTDD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASE-EXCISION-REPAIR; DOUBLE-STRAND BREAK; COLI ENDONUCLEASE-III; ATM-DEPENDENT PHOSPHORYLATION; PURIFIED HUMAN PROTEINS; HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE; APURINIC APYRIMIDINIC SITES; YEAST CHECKPOINT PROTEIN; INDUCED G2 ARREST; G-A MISPAIRS;
Keywords:
DNA damaging agents; DNA repair; genome instability; cell cycle checkpoints; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
216
Recensione:
Indirizzi per estratti:
Indirizzo: Norbury, CJ Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund Labs, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS, Oxford OX3 9DS, England
Citazione:
C.J. Norbury e I.D. Hickson, "Cellular responses to DNA damage", ANN R PHARM, 41, 2001, pp. 367-401

Abstract

Cells are constantly under threat from the cytotoxic and mutagenic effectsof DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents. Endogenous damaging agents include methylating species and the reactive oxygen species that arise during respiration. Although diverse responses are elicited in cells following DNA damage, thisreview focuses on three aspects: DNA repair mechanisms, cell cycle checkpoints, and apoptosis. Because the areas of nucleotide excision repair and mismatch repair have been covered extensively in recent reviews (1-6), we restrict our coverage of the DNA repair field to base excision repair and DNA double-strand break repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:00:12