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Titolo:
Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2and p53
Autore:
Beenken, SW; Grizzle, WE; Crowe, DR; Conner, MG; Weiss, HL; Sellers, MT; Krontiras, H; Urist, MM; Bland, KI;
Indirizzi:
Univ Alabama, Dept Surg, Ctr Comprehens Canc, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ehens Canc, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Ctr Comprehens Canc, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ehens Canc, Birmingham, AL 35294 USA Univ Alabama, Biostat Unit, Ctr Comprehens Canc, Birmingham, AL USA Univ Alabama Birmingham AL USA , Ctr Comprehens Canc, Birmingham, AL USA
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 5, volume: 233, anno: 2001,
pagine: 630 - 637
SICI:
0003-4932(200105)233:5<630:MBFBCP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCTAL CARCINOMA INSITU; PROTEIN EXPRESSION; CELL-PROLIFERATION; TUMOR SUPPRESSOR; IMMUNOHISTOCHEMICAL EVALUATION; HER-2/NEU PROTEINS; C-MYC; BENIGN; OVEREXPRESSION; ONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Beenken, SW Univ Alabama, Dept Surg, Ctr Comprehens Canc, Suite 321,1922 7th Ave S, Birmingham, AL 35294 USA Univ Alabama Suite 321,1922 7th Ave S Birmingham AL USA 35294
Citazione:
S.W. Beenken et al., "Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2and p53", ANN SURG, 233(5), 2001, pp. 630-637

Abstract

Objective To assess the prognostic significance of molecular biomarkers, particularly c-erbB-2 and p53, through study of prospective clinical data and archival breast cancer tissues for women accrued to the Alabama Breast Cancer Project. Summary Background Data Defining molecular abnormalities in breast cancer is an important strategy for early detection, assessment of prognosis, and treatment selection. Evidence is strong that selective biomarkers, including c-erbB-2 and p53, have prognostic significance in breast cancer. Few studies have analyzed the prognostic significance of coexpression of biomarkers. Methods Study patients were those accrued to the Alabama Breast Cancer Project (1975-1978) who had archival breast cancer tissues available for analysis, Criteria for entrance into the Alabama Breast Cancer Project were T1-3breast cancer with MO status. Age, nodal status, and histologic grade werealso documented. Patients were randomized to radical versus modified radical mastectomy, and node-positive patients were also randomized to adjuvant chemotherapy (cyclophosphamide, methotrexate, and 5-fluorouracil [CMF]) versus melphalan. Archival breast cancer tissues were studied for c-erbB-2, TGF-alpha, p53, cathepsin D, bcl-2, and estrogen and progesterone receptor expression using immunohistochemistry. Survival curves were developed using the Kaplan-Meier method. Univariate analysis was performed using the log-rank test, multivariate analysis using a rank regression model. Results Three hundred eleven patients were accrued to the Alabama Breast Cancer Project, and paraffin-embedded breast cancer tissues for 90 patients were available for immunohistochemical analysis of molecular biomarkers. Univariate analysis showed nodal status, c-erbB-2 expression, and p53 expression to have prognostic significance, Coexpression of c-erbB-2 and p53 was also found to have prognostic significance by the log-rank test, Multivariate analysis showed T stage, nodal status, c-erbB-2 expression, and p53 expression to have independent prognostic significance. Conclusions These data suggest that c-erbB-2 and p53 expression in breast cancer have prognostic significance. After median follow-up of 16 years, coexpression of c-erbB-2 and p53 may have more prognostic significance than traditional prognostic factors such as T stage and nodal status, Prospectivestudy of large numbers of patients with breast cancer is encouraged to validate these findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:01:43