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Titolo:
Postnatal maturation of human GAB(A) receptors measured with positron emission tomography
Autore:
Chugani, DC; Muzik, O; Juhasz, C; Janisse, JJ; Ager, J; Chugani, HT;
Indirizzi:
Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA Childrens HospMichigan Detroit MI USA 48201 ediat, Detroit, MI 48201 USA Childrens Hosp Michigan, Dept Radiol, Detroit, MI 48201 USA Childrens HospMichigan Detroit MI USA 48201 adiol, Detroit, MI 48201 USA Childrens Hosp Michigan, Dept Neurol, Detroit, MI 48201 USA Childrens HospMichigan Detroit MI USA 48201 eurol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Ctr Hlth Care Effectiveness Res, Detroit, MI USA Wayne State Univ Detroit MI USA Care Effectiveness Res, Detroit, MI USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 49, anno: 2001,
pagine: 618 - 626
SICI:
0364-5134(200105)49:5<618:PMOHGR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBUNIT MESSENGER-RNAS; GABA-A RECEPTOR; AMINOBUTYRIC ACID(A) RECEPTORS; SEROTONIN SYNTHESIS CAPACITY; HUMAN-BRAIN; BENZODIAZEPINE RECEPTORS; VISUAL-CORTEX; CEREBRAL-CORTEX; C-11 FLUMAZENIL; STRIATE CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Chugani, DC Childrens Hosp Michigan, PET Ctr, 3901 Beaubien Blvd, Detroit,MI 48201 USA Childrens Hosp Michigan 3901 Beaubien Blvd Detroit MI USA 48201
Citazione:
D.C. Chugani et al., "Postnatal maturation of human GAB(A) receptors measured with positron emission tomography", ANN NEUROL, 49(5), 2001, pp. 618-626

Abstract

During brain development in nonhuman primates, there are large changes in GABA,receptor binding and subunit expression. An understanding of human GABAA receptor ontogeny is highly relevant in elucidating the pathophysiology of neurodevelopmental disorders in which GABAergic mechanisms play a role as well as in understanding differences that occur during development in thepharmacology of drugs acting on this system. We have measured age-related changes in the brain distribution of the GABA(A) receptor complex in vivo using positron emission tomography (PET) in epileptic children under evaluation for surgical treatment. PET imaging was performed using the tracer [C-11]flumazenil (FMZ), a ligand that binds to ex subunits of the GABA, receptor. FMZ binding was quantified using a two-compartment model yielding valuesfor the volume of distribution (VD) Of the tracer in tissue. Ah brain regions studied showed the highest value for FMZ VD at the youngest age measured (2 years), and the values then decreased exponentially with age. Medial temporal lobe structures, primary visual cortex, and thalamus showed larger differences between values for age 2 years and adults (approximately 50% decrease) than did basal ganglia, cerebellum, and other cortical regions (25-40% decreases). Furthermore, subcortical regions reached adult values earlier (14-17.5 years) than did cortical regions (18-22 years). The ontogeny data of FMZ VD from children may contribute to understanding regional differences in synaptic plasticity as well as improve rational therapeutic use of drugs acting at the GABA(A) receptor in the pediatric population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:44:54