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Titolo:
THE LOSARTAN INTERVENTION FOR END-POINT REDUCTION (LIFE) IN HYPERTENSION STUDY - RATIONALE, DESIGN, AND METHODS
Autore:
DAHLOF B; DEVEREUX R; DEFAIRE U; FYHRQUIST F; HEDNER T; IBSEN H; JULIUS S; KJELDSEN S; KRISTIANSON K; LEDERBALLEPEDERSEN O; LINDHOLM LH; NIEMINEN MS; OMVIK P; OPARIL S; WEDEL H;
Indirizzi:
OSTRA UNIV HOSP,CTU GOTHENBURG SWEDEN CORNELL UNIV,MED CTR,NEW YORK HOSP NEW YORK NY 10021 ULLEVAL HOSP OSLO NORWAY UNIV MICHIGAN,CTR MED ANN ARBOR MI 48109 UNIV HELSINKI,CENT HOSP HELSINKI FINLAND KAROLINSKA HOSP S-10401 STOCKHOLM SWEDEN GLOSTRUP UNIV HOSP GLOSTRUP DENMARK VIBORG HOSP VIBORG DENMARK LUND UNIV LUND SWEDEN HAUKELAND HOSP N-5021 BERGEN NORWAY UNIV ALABAMA BIRMINGHAM AL 00000 SAHLGRENS UNIV HOSP GOTHENBURG SWEDEN NORDIC SCH PUBL HLTH GOTHENBURG SWEDEN MERCK RES LABS SCANDINAVIA STOCKHOLM SWEDEN
Titolo Testata:
American journal of hypertension
fascicolo: 7, volume: 10, anno: 1997,
parte:, 1
pagine: 705 - 713
SICI:
0895-7061(1997)10:7<705:TLIFER>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; II RECEPTOR ANTAGONIST; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; ELECTROCARDIOGRAPHIC DETECTION; CARDIOVASCULAR MORBIDITY; PROGNOSTIC IMPLICATIONS; CARDIAC-HYPERTROPHY; ANGIOTENSIN SYSTEM; MORTALITY;
Keywords:
HYPERTENSION; CARDIOVASCULAR; MORTALITY-MORBIDITY; ATENOLOL; LOSARTAN; ANGIOTENSIN II BLOCKER; INTERVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
B. Dahlof et al., "THE LOSARTAN INTERVENTION FOR END-POINT REDUCTION (LIFE) IN HYPERTENSION STUDY - RATIONALE, DESIGN, AND METHODS", American journal of hypertension, 10(7), 1997, pp. 705-713

Abstract

The treatment of hypertension mainly with diuretics and beta blockersreduces cardiovascular mortality and morbidity, largely due to a decreased incidence of stroke, whereas the beneficial effects of antihypertensive therapy on the occurrence of coronary events have been less than expected from epidemiological studies. Furthermore, treated hypertensive patients still have a higher cardiovascular complication rate, compared with matched normotensives. This is particularly evident in patients with left ventricular hypertrophy (LVH), a major independent risk indicator for cardiovascular disease. In addition to elevating blood pressure, angiotensin II (A-II) exerts an important influence on cardiac structure and function, stimulating-cell proliferation and growth. Thus, to further reduce morbidity and mortality when treating hypertensive patients, it may be important to effectively block the effects of A-II. This can be achieved directly at the A-II receptor level by losartan, the first of a new class of antihypertensive agents. It therefore seems pertinent to investigate whether selective A-II receptor blockade with losartan not only lowers blood pressure but also reduces LVH more effectively than current therapy, and thus improves prognosis. The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study is a double-blind, prospective, parallel group study designedto compare the effects of losartan with those of the beta-blocker atenolol on the reduction of cardiovascular morbidity and mortality in approximately 8,300 hypertensive patients (initial sitting diastolic blood pressure 95 to 115 mm Hg or systolic blood pressure 160 to 200 mm Hg) with electrocardiographically documented LVH. The study, which willcontinue for at least 4 years and until 1,040 patients experience oneprimary endpoint, has been designed with a statistical power that will detect a difference of at least 15% between groups in the incidence of combined cardiovascular morbidity and mortality. It is also the first-prospective study with adequate power to link reversal of LVH to reduction in major cardiovascular events. The rationale of the study, which will involve more than 800 clinical centers in Scandinavia, the United Kingdom, and the United States, is discussed, and the major features of its design and general organization are described. On April 30,1997, when inclusion was stopped, 9,218 patients had been randomized. (C) 1997 American Journal of Hypertension, Ltd.

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Documento generato il 29/03/20 alle ore 03:03:26