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Titolo:
EFFECT OF BOLUS INJECTION VERSUS CONTINUOUS-INFUSION OF FUROSEMIDE ONDIURESIS AND NEUROHORMONAL ACTIVATION IN PATIENTS WITH SEVERE CONGESTIVE-HEART-FAILURE
Autore:
AASER E; GULLESTAD L; TOLLOFSRUD S; LUNDBERG J; HALL C; DJOSELAND O; KJEKSHUS J; FORFANG K;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED B N-0027 OSLO NORWAY KAROLINSKA INST,INST PHYSIOL & PHARMACOL STOCKHOLM SWEDEN
Titolo Testata:
Scandinavian journal of clinical & laboratory investigation
fascicolo: 4, volume: 57, anno: 1997,
pagine: 361 - 367
SICI:
0036-5513(1997)57:4<361:EOBIVC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA NOREPINEPHRINE; NEUROHUMORAL AXIS; ENDOTHELIN;
Keywords:
ANTIDIURETIC HORMONE; BIG-ENDOTHELIN; EPINEPHRINE; NEUROPEPTIDE Y; NOREPINEPHRINE; PRO-ANF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Aaser et al., "EFFECT OF BOLUS INJECTION VERSUS CONTINUOUS-INFUSION OF FUROSEMIDE ONDIURESIS AND NEUROHORMONAL ACTIVATION IN PATIENTS WITH SEVERE CONGESTIVE-HEART-FAILURE", Scandinavian journal of clinical & laboratory investigation, 57(4), 1997, pp. 361-367

Abstract

Previous studies have demonstrated that continuous infusion of furosemide results in increased diuresis and natriuresis compared with bolusadministration of the drug in patients with severe heart failure. We reasoned that continuous infusion of furosemide caused less activationof neurohumoral mechanisms, since other studies have shown that bolusadministration of furosemide may activate this system. We therefore tested the hypothesis that continuous administration of furosemide would increase water and sodium excretion due to less activation of neurohormones. Eight patients with severe heart failure were studied during continuous infusion over 24 h and bolus injections of furosemide twicedaily in a randomized cross-over study. Bolus administration of furosemide increased diuresis and natriuresis significantly in the first 4 h after administration compared with continuous administration, but this was later reversed, resulting in similar 24 h total output. The neurohormones measured at baseline were all markedly elevated. Neither regimens of furosemide caused any further significant changes in neurohumoral response except that pro-ANF decreased more during the first 8 hafter bolus administration compared to continuous infusion. This study:has demonstrated that bolus administration of furosemide in conventional doses is equally effective as continuous intravenous infusion in patients with severe heart failure. This may be due to maximal neurohormonal activation in severe heart failure (NYHA III-IV) which could not be further activated by bolus administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:30:26