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Titolo:
Effect of locally applied GM-CSF on oral mucositis after stem cell transplantation: a prospective placebo-controlled double-blind study
Autore:
van der Lelie, H; Thomas, BLM; van Oers, RHJ; Ek-Post, M; Sjamsoedin, SAS; van Dijk-Overtoom, ML; Timmer, JG; von dem Borne, AEGK;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Hematol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Hosp Dent, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Pharm, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
ANNALS OF HEMATOLOGY
fascicolo: 3, volume: 80, anno: 2001,
pagine: 150 - 154
SICI:
0939-5555(2001)80:3<150:EOLAGO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NECK-CANCER PATIENTS; GRANULOCYTE-COLONY; MARROW TRANSPLANTATION; CHEMOTHERAPY; PREVENTION; HEAD; THERAPY;
Keywords:
mucositis; stem cell transplantation; GM-CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: van der Lelie, H Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Hematol, Meibergdreef9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
H. van der Lelie et al., "Effect of locally applied GM-CSF on oral mucositis after stem cell transplantation: a prospective placebo-controlled double-blind study", ANN HEMATOL, 80(3), 2001, pp. 150-154

Abstract

Oral mucositis is a frequent side effect of myeloablative chemo- and radiotherapy preceding stem cell transplantation. It causes pain, poor food intake, and is a port of entry for infection. We studied whether GM-CSF appliedtopically in the oral cavity can prevent or ameliorate this mucositis. In 36 consecutive patients undergoing a stem cell transplantation, we performed a double-blind placebo-controlled study of 300 mug GM-CSF in a 2% methylcellulose gel daily versus a 2% methylcellulose gel alone. Both were locallyapplied in the oral cavity. The primary end-point was mucositis as measured by the WHO toxicity scale for mucositis, oral assessment scale, and a subjective pain scale, all scored daily. The secondary end-points were need togive parenteral nutrition and morphine, incidence of fever and infections,and duration of neutropenia and hospitalization. No differences were foundin the median subjective pain scores, WHO scores, and oral assessment scores between the placebo and the GM-CSF groups. In both groups, nine patientsrequired morphine for pain control. Ten patients in the placebo group and Ii in the GM-CSF group received parenteral nutrition. Documented infections, use of broad-spectrum antibiotics, and number of days with fever were similar in the placebo and the GM-CSF groups. The duration of neutropenia below 0.5x10(9)/l (median 14.5 days in the placebo group versus 17 days in the GM-CSF group) and the duration of hospitalization (28.5 versus 29 days) wasalso not significantly different. We found no beneficial effect of 300 mugGM-CSF dissolved in a 2% methylcellulose gel applied locally for chemo- and radiotherapy-induced mucositis in patients undergoing a stem cell transplantation.

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Documento generato il 09/04/20 alle ore 07:06:27