Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Testosterone mediates satellite cell activation in denervated rat levator ani muscle
Autore:
Nnodim, JO;
Indirizzi:
Univ Michigan, Inst Gerontol, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI48109 USA Univ Michigan Ann Arbor MI USA 48109 l & Dev Biol, Ann Arbor, MI48109 USA
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 1, volume: 263, anno: 2001,
pagine: 19 - 24
SICI:
0003-276X(20010501)263:1<19:TMSCAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE GROWTH-FACTOR; SKELETAL-MUSCLE; ANDROGENS; DIFFERENTIATION; PROLIFERATION; ACCUMULATION; CASTRATION; MECHANISM; NUCLEUS; MOUSE;
Keywords:
rat; levator ani; satellite cells; denervation; castration; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nnodim, JO Univ Michigan, Inst Gerontol, Sch Med, Dept Cell & Dev Biol, Rm913,300 N Ongallo Bldg,Box 2007, Ann Arbor, MI 48109 USA Univ Michigan Rm 913,300 N Ongallo Bldg,Box 2007 Ann Arbor MI USA 48109
Citazione:
J.O. Nnodim, "Testosterone mediates satellite cell activation in denervated rat levator ani muscle", ANAT REC, 263(1), 2001, pp. 19-24

Abstract

Denervation stimulates quiescent satellite cells in skeletal muscle to reenter the cell cycle. In the androgen-sensitive rat levator ani muscle (LA),this mitotic response to loss of neural input fails to occur in castrated animals. To elucidate the role of androgens in denervation-induced satellite cell proliferation, the denervated LA of castrated rats (Group A) was compared with that of animals infixed with testosterone implants after castration (Group B). Mean myofiber cross-sectional areas (Group A: 362.95 mum(2) /- 27.74; Group B: 403.13 mum(2) +/- 53.87) and linear nuclear densities (Group A: 74.07 mm(-1) +/- 17.58; Group B: 104.13 mm(-1) +/- 4.06) were similar (P > 0.05) in both groups. The androgen-deprived myofibers of Group A, however, had a significantly lower nuclear content (271.0 +/- 74.91 vs. 1,285.80 +/- 81.74 in Group B; P < 0.05) on account of their considerably shorter mean length (3.44 mm +/- 0.29 vs. 12.31 mm +/- 0.92 in Group B; P < 0.05). The proportional representation of satellite cells in hormone-replaced,denervated muscle was more than twice that in the untreated group (Group B: 5.15 +/- 0.83% vs. Group A: 2.28 +/- 0.23%; P < 0.05). In absolute terms,the satellite cell number in Group B was approximately an order of magnitude greater than in Group A (408.4 x 10(3) vs. 38.08 x 10(3)). The results confirm the absence of testosterone as the factor responsible for the inability of satellite cells in the LA of castrated rats to respond mitotically to the withdrawal of neural input after denervation. Anat Rec 263:19-24, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:37:14