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Titolo:
Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells - Effects on platelet-activating factor receptor expression
Autore:
Ishizuka, S; Yamaya, M; Suzuki, T; Nakayama, K; Kamanaka, M; Ida, S; Sekizawa, K; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Univ Tsukuba, Inst Clin Med, Dept Resp Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 p Med, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 459 - 468
SICI:
1044-1549(200104)24:4<459:AESTAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TRACHEAL EPITHELIUM; TUMOR-NECROSIS-FACTOR; INDUCED LUNG INJURY; KAPPA-B ACTIVATION; ENDOTHELIAL-CELLS; GENE-EXPRESSION; IN-VIVO; ASPIRATION; TRANSCRIPTION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryomachi Sendai Miyagi Japan 9808574 4, Japan
Citazione:
S. Ishizuka et al., "Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells - Effects on platelet-activating factor receptor expression", AM J RESP C, 24(4), 2001, pp. 459-468

Abstract

To examine the effects of acid exposure on the adherence of Streptococcus pneumoniae to cultured human tracheal epithelial cells, cells were exposed to acid at various pH levels, and various concentrations of S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to cultured human tracheal epithelial cells increased after acid exposure. Y-24180, a specific inhibitor of the receptor for the platelet-activating factor(PAF) and PAF itself decreased the number of S. pneumoniae adhering to cultured human tracheal epithelial cells after acid exposure. Acid exposure increased the activation of transcription factor nuclear factor (NF)-kappaB and the expression of protein and messenger RNA (mRNA) of the PAF receptor. The pyrrolidine derivative of dithiocarbamate (PDTC), an inhibitor of NF-KB, also decreased the number of S. pneumoniae adhering to the cultured humantracheal epithelial cells after acid exposure. Acid exposure increased thecontent of interleukin (IL)-1 alpha and IL-1 beta in the culture supernatants, but monoclonal antibodies to IL-1 alpha and IL-1 beta failed to inhibit the increased number of S. pneumoniae adhering to cultured human trachealepithelial cells after acid exposure. These findings suggest that acid exposure stimulates the adherence of S. pneumoniae to the airway epithelial cells via increases in PAF receptors, Increases in PAF receptor expression may be, in part, mediated via activation of transcription factors and subsequent PAF receptor mRNA expression by acid exposure. Increased adherence of S. pneumoniae may be one of the reasons why pneumonia develops after gastricjuice aspiration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:50:46