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Titolo:
Decreased steroid responsiveness at night in nocturnal asthma - Is the macrophage responsible?
Autore:
Kraft, M; Hamid, Q; Chrousos, GP; Martin, RJ; Leung, DYM;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Div Pulm Sci & Crit Care Med,Dept Med, Denver, CO 80206 USA Univ Colorado Denver CO USA 80206 Care Med,Dept Med, Denver, CO 80206 USA Univ Colorado, Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Div Pulm Sci & Crit Care Med,Dept Pediat, Denver, CO 80206 USA Univ Colorado Denver CO USA 80206 e Med,Dept Pediat, Denver, CO 80206 USA McGill Univ, Meakins Christie Labs, Montreal, PQ, Canada McGill Univ Montreal PQ Canada akins Christie Labs, Montreal, PQ, Canada NIH, Dev Endocrinol Branch, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 , Dev Endocrinol Branch, Bethesda, MD 20892 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 163, anno: 2001,
pagine: 1219 - 1225
SICI:
1073-449X(200104)163:5<1219:DSRANI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLUCOCORTICOID RECEPTOR; NF-KAPPA-B; BETA-ISOFORM; BINDING AFFINITY; RESISTANT ASTHMA; BRONCHIAL-ASTHMA; MESSENGER-RNA; CELL-FUNCTION; EXPRESSION; INTERLEUKIN-13;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kraft, M Univ Colorado, Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Div Pulm Sci & Crit Care Med,Dept Med, 1400 Jackson St,Room J107, Denver, CO 80206 USA Univ Colorado 1400 Jackson St,Room J107 Denver CO USA 80206 6 USA
Citazione:
M. Kraft et al., "Decreased steroid responsiveness at night in nocturnal asthma - Is the macrophage responsible?", AM J R CRIT, 163(5), 2001, pp. 1219-1225

Abstract

As peripheral blood mononuclear cells from patients with nocturnal asthma (NA) exhibit reduced steroid responsiveness at 4:00 A.M. as compared with 4:00 P.M,, We hypothesized that NA is-associated with increased nocturnal airway cell expression of GRP, an endogenous inhibitor of steroid action. Tensubjects with NA and seven subjects with nonnocturnal asthma (NNA) underwent bronchoscopy with bronchoalveolar lavage (BAL) at 4:00 P.M. and 4:00 A.M. BAL lymphocytes and macrophages were incubated with dexamethasone (DEX) at 10(-5) to 10(-8) M. DEX suppressed proliferation of BAL lymphocytes similarly at 4:00 P.M. and 4:00 A,M. in both groups. However, BAL macrophages from NA exhibited less suppression of IL-8 and TNF-c( production by DEX at 4:00 A.M. as compared with 4:00 P.M. (P = 0.0001), whereas in the NNA group DEX suppressed IL-8 and TNF-alpha production equally at both time points. GRP expression was increased at night only in NA, primarily due to significantly increased expression by BAL macrophages (p = 0.008). IL-13 mRNA expression was increased at night but only in the NA group and addition of neutralizing antibodies to IL-13 reduced GRP expression by BAL macrophages. We conclude that the airway macrophage may be the airway inflammatory cell driving the reduction in steroid responsiveness at night in NA, and this functionis modulated by IL-13.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:59:03