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Titolo:
The relationship between atonic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection
Autore:
Corne, JM; Lau, L; Scott, SJ; Davies, R; Johnston, SL; Howarth, PH;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, Southampton SO1 6HU, Hants, England Univ Southampton Southampton Hants England SO1 6HU O1 6HU, Hants, England Imperial Coll Sch Med, NHU St Marys, Dept Resp Med, London, England Imperial Coll Sch Med London England ys, Dept Resp Med, London, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 163, anno: 2001,
pagine: 1101 - 1107
SICI:
1073-449X(200104)163:5<1101:TRBASA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHINOVIRUS INFECTION; CYTOKINE PRODUCTION; ASTHMATIC SUBJECTS; HISTAMINE-RELEASE; COMMON COLD; IN-VIVO; VIRUSES; EXACERBATIONS; INTERFERON; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Corne, JM Queens Med Ctr, Dept Resp Med, Level D,South Block, Nottingham NG7 2UH, England Queens Med Ctr Level D,South Block Nottingham England NG7 2UH d
Citazione:
J.M. Corne et al., "The relationship between atonic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection", AM J R CRIT, 163(5), 2001, pp. 1101-1107

Abstract

We examined the influence of atopy on virus-induced airway inflammation bycomparing the nasal response to naturally acquired upper respiratory tractinfection in atopic and nonatopic subjects by measurement of cytokine, chemokine, and mediator levels in nasal lavage from 44 adults (23 atopic) taken during the acute and the convalescent phases of the common cold. Nasal aspirates were examined for the presence of upper respiratory viruses by RT-PCR. In atopic and nonatopic subjects there were increased levels of IL-1 beta, IL-6, IL-8, TNF-alpha, RANTES, sICAM-1, MPO, ECP, IL-10, and IFN-gamma in nasal lavage during the acute compared with the convalescent phase (p < 0.001). During the acute phase histamine levels were significantly higher in the atopic than in the nonatopic subjects (p < 0.05), whereas IL-10 levels were significantly greater in the nonatopic than in the atopic subjects (p < 0.05). At convalescence levels of IL-1 beta, IL-6, sICAM-1, ECP, RANTESand albumin were significantly higher in the atopic group (p < 0.05). An upper respiratory tract virus was found in 27 volunteers (61%) during the acute stage and in two volunteers (4%) at convalescence. We conclude that virus-induced inflammatory changes within the nose are more prolonged in atopic than in nonatopic subjects and that this is associated with reduced IL-10levels in atopic compared with nonatopic subjects during the acute phase of upper respiratory tract infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:15:11