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Titolo:
Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access
Autore:
Weiss, MF; Scivittaro, V; Anderson, JM;
Indirizzi:
Univ Hosp Cleveland, Dept Med, Div Nephrol, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 phrol, Cleveland, OH 44106 USA Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 5, volume: 37, anno: 2001,
pagine: 970 - 980
SICI:
0272-6386(200105)37:5<970:OSAIEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCATION END-PRODUCTS; HUMAN SAPHENOUS-VEIN; INTIMAL HYPERPLASIA; LIPID-PEROXIDATION; TRANSFORMING GROWTH-FACTOR-BETA-1; CARBONYL STRESS; OXIDANT STRESS; ORGAN-CULTURE; RENAL-FAILURE; GRAFTS;
Keywords:
arteriovenous (AV) fistula; expanded polytetrafluoroethylene (ePTFE) graft; endothelin-1 (ET-1); N-epsilon(carboxymethyl)lysine (CML); 4-hydroxy-2,3-nonenol (HNE); transforming growth factor-beta (TGF-beta); platelet-derived growth factor (PDGF); intimal hyperplasia; neointima; pseudointima; anastomotic hyperplasia; hemodialysis (HD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, MF Univ Hosp Cleveland, Dept Med, Div Nephrol, 11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA44106 USA
Citazione:
M.F. Weiss et al., "Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access", AM J KIDNEY, 37(5), 2001, pp. 970-980

Abstract

The pathological role of oxidative stress in patients treated by hemodialysis has gained increasing recognition in recent years. Because complications related to vascular access are a major source of morbidity, immunohistochemical evidence of oxidative stress and activation of growth factors were examined in native arteriovenous (AV) fistulae (n = 11) and expanded polytetrafluoroethylene (ePTFE) grafts (n = 15) recovered from hemodialysis patients at the time of surgical revision or resection. To show the presence of oxidative stress in tissues, three markers were chosen: N-epsilon(carboxymethyl)lysine, a structurally identified advanced glycation end product; 4-hydroxy-2,3-nonenol, a lipid peroxidation product; and redox-active transitionmetals bound to proteins, a source of Fenton chemistry-generated free radicals. Markers of cell growth and proliferation were endothelin-1 (ET-1), a potent mitogenic peptide implicated in the formation of intimal hyperplasia; transforming growth factor-beta (TGF-beta), a stimulus to vascular cell growth and matrix production; and platelet-derived growth factor (PDGF), a mediator of intimal hyperplasia. All specimens studied showed significant intimal hyperplasia. In general, the neointima close to the vascular lumen ofthe AV fistula and the pseudointima close to the lumen of the ePTFE graft were positive for oxidative stress markers. At sites of injury, especially in the presence of histological evidence of inflammation and healing, expression of oxidative markers was particularly intense. Prominent staining of PDGF was shown at sites of anastomotic hyperplasia and in neovasculature. TGF-beta was associated with proliferation or repair in both AV fistulae andePTFE grafts. ET-1 staining was most intense in the neointima and pseudointima. This study showed histochemical colocalization of markers of oxidative stress with growth factors known to contribute to intimal hyperplasia. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:52:37