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Titolo:
Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I-IV in enterally fed rats
Autore:
Briet, F; Jeejeebhoy, KN;
Indirizzi:
Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 t Med, Toronto, ON M5S 1A8, Canada
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 5, volume: 73, anno: 2001,
pagine: 975 - 983
SICI:
0002-9165(200105)73:5<975:EOHFAR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; PROTEIN-ENERGY MALNUTRITION; OXIDATIVE-PHOSPHORYLATION; RESPIRATORY-CHAIN; OXYGEN-CONSUMPTION; ANOREXIA-NERVOSA; SKELETAL-MUSCLE; NUCLEAR; NORMALIZATION; LYMPHOCYTES;
Keywords:
protein-energy restriction; malnutrition; refeeding; mitochondrial complexes I-IV; electron transport chain; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jeejeebhoy, KN Univ Toronto, Dept Med, Med Sci Bldg,Room 6352, Toronto, ONM5S 1A8, Canada Univ Toronto Med Sci Bldg,Room 6352 Toronto ON Canada M5S 1A8
Citazione:
F. Briet e K.N. Jeejeebhoy, "Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I-IV in enterally fed rats", AM J CLIN N, 73(5), 2001, pp. 975-983

Abstract

Background: Previous studies suggested that cell energetics are altered bymalnutrition,Objective: We hypothesized that nutritional manipulations influence mitochondrial enzyme activities of the electron transport chain in both skeletal muscle and blued mononuclear cells. Design: After a gastrostomy tube was inserted, 44 rats were randomly assigned to 1 of 4 experimental groups: control fed (CF; 363 kJ/d for 7 d), hypoenergetic fed (HF; 92 kJ/d fur 7 d), hypoenergetic protein refed (HPR; 92 kJ/d fur 7 d and then 19 kJ/d fur 1 d), and hypoenergetic glucose refed (HGR; 92 kJ/d for 7 d and then 129 kJ/d fur 1 d), The protein and glucose contents of the liquid formulas were different for the HPR and HGR groups. Aftermitochondria were isolated From the soleus muscle, the activities of complexes I-IV were measured spectrophotometrically. Because of the lack of available tissue, only the activity of complex T was measured in the mononuclear cell extract. Results: The recovery of complex activities in the CF and HF groups was not significantly different in the mitochondrial fraction of the soleus muscle. Compared with that in the CF group, the activities of complexes I-III inthe mitochondrial fraction of the soleus muscle and the activity of complex I in mononuclear cells were significantly lower in the HF group. The activities of complexes I-III in the mitochondrial fraction of the soleus muscle and the activity of complex I in mononuclear sells were significantly higher in the HPR than in the HF group. The activity of complex IV was generally not affected by nutritional manipulations. Conclusion: Malnutrition, decreases activities of mitochondrial complexes,which are restored by protein bur not glucose refeeding.

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Documento generato il 22/01/20 alle ore 12:40:46