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Titolo:
Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans
Autore:
Beaumier-Gallon, G; Dubois, C; Senft, M; Vergnes, MF; Pauli, AM; Portugal, H; Lairon, D;
Indirizzi:
Unite 476 INSERM, F-13009 Marseille, France Unite 476 INSERM Marseille France F-13009 ERM, F-13009 Marseille, France Univ Mediterrannee, Fac Pharm, Chim Analyt Lab, Marseille, France Univ Mediterrannee Marseille France Chim Analyt Lab, Marseille, France
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 5, volume: 73, anno: 2001,
pagine: 870 - 877
SICI:
0002-9165(200105)73:5<870:DCISII>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE-RICH LIPOPROTEINS; BILIARY CHOLESTEROL; PLASMA-CHOLESTEROL; MASS-SPECTROMETRY; NORMAL WOMEN; ABSORPTION; METABOLISM; LIPEMIA; APOLIPOPROTEINS; EFFICIENCY;
Keywords:
lipid; digestion; absorption; chylomicron; postprandial metabolism; men; heptadeuterated cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lairon, D Unite 476 INSERM, 18 Ave Mozart, F-13009 Marseille, France Unite476 INSERM 18 Ave Mozart Marseille France F-13009 France
Citazione:
G. Beaumier-Gallon et al., "Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans", AM J CLIN N, 73(5), 2001, pp. 870-877

Abstract

Background: The process of intestinal absorption and chylomicron resecretion of dietary cholesterol in humans is poorly understood. Objective: The present study aimed to test the hypothesis that dietary cholesterol ingested during a given meal is resecreted into chylomicrons (and plasma) during several subsequent postprandial periods. Design: Seven healthy subjects ingested 3 comparable mixed test meals (at 0, 8, and 24 h) containing a given amount of fat (49 g) and cholesterol (157 mg); blood samples were taken 3 and 6 h after each test meal and 48 and 72 h after the beginning of the experiment. Heptadeuterated dietary cholesterol was present in the first test meal only, enabling its specific determination with use of gas chromatography-mass spectrometry. Chylomicrons, LDL, and HDL were isolated and lipids were quantified. Results: In apolipoprotein B-48-containing chylomicrons, deuterated cholesterol concentrations were moderate after the first meal (1.3 x 10(-4) mmol/L), reached a maximum after the second meal (2.4 x 10(-4) mmol/L), and werestill elevated after the third meal (1.7 x 10(-4) mmol/L). In plasma, LDL and HDL cholesterol enrichment in deuterated cholesterol was lower than in chylomicrons and plateaued after 24-48 h. Estimates of newly secreted exogenous deuterated cholesterol in chylomicrons indicate that 30.7%, 55.2%, and14.1% of the total was secreted after the first, second, and third meals, respectively. Conclusion: Ingested dietary cholesterol is secreted by the small intestine in chylomicrons into the circulation during greater than or equal to3 subsequent postprandial periods in healthy humans. This likely results from a complex multistep intestinal processing of cholesterol with dietary fat as a driving force.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:09:46