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Titolo:
M-mode echocardiographic predictors at six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study)
Autore:
Gardin, JM; McCleland, R; Kitzman, D; Lima, JAC; Bommer, W; Klopfenstein, HS; Wong, ND; Smith, VE; Gottdiener, J;
Indirizzi:
Univ Calif Irvine, Dept Med, Div Cardiol, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 , Div Cardiol, Irvine, CA 92717 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Wake Forest Univ, Sch Med, Dept Med, Div Cardiol, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Univ Calif Davis, Div Cardiol, Davis, CA 95616 USA Univ Calif Davis DavisCA USA 95616 vis, Div Cardiol, Davis, CA 95616 USA Albany Med Coll, Div Cardiol, Albany, NY 12208 USA Albany Med Coll AlbanyNY USA 12208 ll, Div Cardiol, Albany, NY 12208 USA Georgetown Univ, Med Ctr, Dept Med, Div Cardiol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Cardiol, Washington, DC 20007 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 9, volume: 87, anno: 2001,
pagine: 1051 - 1057
SICI:
0002-9149(20010501)87:9<1051:MEPAST>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR MASS; PROGNOSTIC IMPLICATIONS; ESSENTIAL-HYPERTENSION; MORBID EVENTS; HYPERTROPHY; RISK; DILATATION; PATTERNS; ADULTS; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gardin, JM St John Hosp, Div Cardiol, 22151 Moross Rd, Detroit, MI 48236 USA St John Hosp 22151 Moross Rd Detroit MI USA 48236 MI 48236 USA
Citazione:
J.M. Gardin et al., "M-mode echocardiographic predictors at six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study)", AM J CARD, 87(9), 2001, pp. 1051-1057

Abstract

Previous studies have identified a number of echocardiographic variables that predict cardiovascular disease (CVD) events and mortality, but have notfocused on a large elderly cohort. The purpose of this study was to determine whether M-mode echocardiographic variables predicted ail-cause mortality, incident coronary heart disease (CHD), congestive heart failure (CHF), and stroke in a large prospective, multicenter, population-based study. in the Cardiovascular Health Study, a biracial cohort of 5,888 men and women (mean age 73 years) underwent 5-dimensional M-mode echocardiographic measurements of left ventricular (LV) internal dimensions, wail thickness, mass andgeometry, as well as measurement of left atrial dimension and assessment for mitral annular calcium. Participants were followed for 6 to 7 years for incident events; analyses excluded subjects with prevalent disease. One or more echocardiographic measurements were independent predictors of air-cause mortality and incident CHD, CHF, and stroke. After adjustment for anthropometric and traditional CVD risk factors, LV mass was significantly relatedto incident CHD, CHF, and stroke. The highest quartile of LV mass conferred a hazards ratio of 3.36, compared with the lowest quartile, for incident CHF. Furthermore, incident CHF-free survival was significantly lower for participants with LV mass in the highest versus the 2 lowest quartiles (86% vs 97%, respectively, at 2,500 days). Eccentric and concentric LV hypertrophy, respectively, conferred adjusted hazards ratios, compared with normal LVgeometry, of 2.05 and 1.61 for incident CHD, and 2.95 and 3.32 for incident CHF. Thus, in an elderly biracial population, selected 2-dimensional M-mode echocardiographic measurements were important markers of subclinical disease and conferred independent prognostic information for incident CVD events, especially CHF and CHD. (C) 2001 by Excerpta Medica Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:31:06