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Titolo:
Viral load differences in early infection with two HIV-1 subtypes
Autore:
Hu, DJ; Vanichseni, S; Mastro, TD; Raktham, S; Young, NL; Mock, PA; Subbarao, S; Parekh, BS; Srisuwanvilai, L; Sutthent, R; Wasi, C; Heneine, W; Choopanya, K;
Indirizzi:
Minist Publ Hlth, HIV AIDS Collaborat, Nonthaburi 11000, Thailand Minist Publ Hlth Nonthaburi Thailand 11000 t, Nonthaburi 11000, Thailand Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA D & TB Prevent, Atlanta, GA USA Bangkok Metropolitan Adm, Bangkok, Thailand Bangkok Metropolitan Adm Bangkok Thailand olitan Adm, Bangkok, Thailand Ctr Dis Control & Prevent, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis,Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Ctr Infect Dis,Atlanta, GA USA Mahidol Univ, Bangkok 10700, Thailand Mahidol Univ Bangkok Thailand 10700 ahidol Univ, Bangkok 10700, Thailand
Titolo Testata:
AIDS
fascicolo: 6, volume: 15, anno: 2001,
pagine: 683 - 691
SICI:
0269-9370(20010413)15:6<683:VLDIEI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; INJECTING DRUG-USERS; LANGERHANS CELL TROPISM; DISEASE PROGRESSION; NATURAL-HISTORY; HETEROSEXUAL TRANSMISSION; PROSPECTIVE COHORT; GENETIC SUBTYPES; RHESUS MACAQUES; HOMOSEXUAL MEN;
Keywords:
HIV-1 subtypes; viral load; early infection; seroconversion; Thailand; Asia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, DJ Minist Publ Hlth, HIV AIDS Collaborat, DMS 6 Bldg,Tivanon Rd, Nonthaburi 11000, Thailand Minist Publ Hlth DMS 6 Bldg,Tivanon Rd Nonthaburi Thailand 11000 d
Citazione:
D.J. Hu et al., "Viral load differences in early infection with two HIV-1 subtypes", AIDS, 15(6), 2001, pp. 683-691

Abstract

Objectives: Information on early HIV-1 infection has come primarily from studies of persons infected with subtype B in North America and Europe; muchless is known about other subtypes. The purpose of the present study was to compare the virologic and immunologic parameters following seroconversionamong recently-infected persons infected with either of two different HIV-1 subtypes. Method: A prospective cohort study was carried out at methadone treatment clinics administered by the Bangkok Metropolitan Administration, Thailand. A total of 130 HIV-I-infected seroconverters (103 with HIV-1 subtype E and 27 with subtype B) were included in the study. The main outcome measures were serial HIV-1 RNA viral load, natural killer cell percentage, CD4 and CD8lymphocyte counts since seroconversion. Results: The demographic and behavioral characteristics of persons with either subtype were similar. Median RNA viral levels at the earliest time within 3 months of seroconversion were more than three times higher for persons infected with subtype E than subtype B (63 100 versus 18 050 copies/ml, P= 0.001). However, this difference decreased over time such that viral loads were similar at 12, 18, and 24 months following seroconversion. The CD4 and CD8 lymphocyte counts were similar in infections with either subtype during the entire period up to 24 months post-seroconversion. Conclusions: Higher viral loads associated with subtype E may result from intersubtype biological differences; however, the epidemiological dynamics of transmission in Bangkok may have also contributed to this phenomenon. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:31:17