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Titolo:
Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast
Autore:
Chan, JKC; Wong, CSC;
Indirizzi:
Queen Elizabeth Hosp, Dept Pathol, Kowloon, Hong Kong, Peoples R China Queen Elizabeth Hosp Kowloon Hong Kong Peoples R China , Peoples R China
Titolo Testata:
ADVANCES IN ANATOMIC PATHOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 165 - 172
SICI:
1072-4109(200105)8:3<165:LOEITF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-MUTATIONS PROVIDE; GERMLINE MUTATIONS; BETA-CATENIN; N-CADHERIN; PLEURAL MESOTHELIOMAS; NUCLEAR-LOCALIZATION; LUNG ADENOCARCINOMAS; COLORECTAL-CANCER; IN-SITU; EXPRESSION;
Keywords:
gastric cancer; stomach cancer; diffuse-type adenocarcinoma of stomach; signet ring cell carcinoma; breast cancer; lobular carcinoma of breast; E-cadherin; mutation; loss of heterozygosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, JKC Queen Elizabeth Hosp, Dept Pathol, Wylie Rd, Kowloon, Hong Kong,Peoples RChina Queen Elizabeth Hosp Wylie Rd Kowloon Hong Kong Peoples R China
Citazione:
J.K.C. Chan e C.S.C. Wong, "Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast", ADV ANAT PA, 8(3), 2001, pp. 165-172

Abstract

E-cadherin is a form of cell adhesion molecule playing an important role in epithelial cell organization. Loss of function or loss of expression of this molecule due to mutations in the E-cadherin (CDH1) gene has been shown to be a key feature of the diffuse-type gastric adenocarcinoma. Of interest, in gastric adenocarcinoma showing a mixed diffuse and intestinal pattern,loss of E-cadherin is confined to the former component. In the breast, infiltrating lobular carcinoma, characterized by a diffuse permeative growth of neoplastic cells, has similarly been shown to exhibit loss of E-cadherin. Thus the molecular alteration (loss of E-cadherin) provides a plausible explanation for the observed morphologic phenotype of these two tumor types. Finally, rare families characterized by germline mutations in the E-cadherin gene have been shown to be strongly predisposed to the development of gastric cancer (diffuse-type) and/or infiltrating lobular carcinoma of the breast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:36:53