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Titolo:
Preventive effects of ginsenosides on osteopenia of rats induced by ovariectomy
Autore:
Cui, L; Wu, T; Liu, XQ; Li, QN;
Indirizzi:
Guangdong Med Coll, Dept Pharmacol, Zhanjiang 524023, Peoples R China Guangdong Med Coll Zhanjiang Peoples R China 524023 023, Peoples R China Guangdong Med Coll, Bone Biol Lab, Zhanjiang 524023, Peoples R China Guangdong Med Coll Zhanjiang Peoples R China 524023 023, Peoples R China Guangdong Med Coll, Dept Biochem, Zhanjiang 524023, Peoples R China Guangdong Med Coll Zhanjiang Peoples R China 524023 023, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 5, volume: 22, anno: 2001,
pagine: 428 - 434
SICI:
0253-9756(200105)22:5<428:PEOGOO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANABOLIC ACTIONS; BONE; ESTROGEN;
Keywords:
ginseng; 17 alpha-ethynylestradiol; ovariectomy; bone and bones; osteoclasts; developmental bone diseases; histocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Cui, L Guangdong Med Coll, Dept Pharmacol, Zhanjiang 524023, Peoples R China Guangdong Med Coll Zhanjiang Peoples R China 524023 oples R China
Citazione:
L. Cui et al., "Preventive effects of ginsenosides on osteopenia of rats induced by ovariectomy", ACT PHAR SI, 22(5), 2001, pp. 428-434

Abstract

AIM: To determine the effect of ginsenosides (GSL) on ovariectomized rats by analysis of cancellous bone histomorphometry. METHODS: Forty Sprague-Dawley female rats at age of 3 months were sham-operated (Sham, n = 8) and heated orally with vehicle, or ovariectomized (OVX, n = 32 which were divided into three group with n = 8 per group) and treated orally with either vehicle, 17 alpha -ethynylestradiol (EE, 100 mug . kg(-1) . d(-1)), or ginsenosides (GSL) at 100 or 300 mg . kg(-1) . d(-1) for 10 weeks. Double in vivo fluorochrome labeling was administrated. The undecalcified longitudinal proximal tibial metaphyseal sections were cut and stained with Goldner's Trichrome (4-mum thickness) or unstained (8-mum thickness) for the bone histomorphometric analysis. RESULTS: After 10 weeks post OVX the cancellous bone masswas lost markedly and showed high bone turnover indices (increased bone resorption and formation). EE decreased the resorptive surface and bone formation rate related to bone turnover and prevented bone loss. GSL at the two doses (100 and 300 mg . kg(-1) . d(-1)) reduced the resorptive surfaces as did EE, but did not depress the mineral bone formation. High dose of GSL greatly increased bone mass and had a tendency to decrease bone turnover whencompared with OVX group. CONCLUSION: GSL partially prevented OVX-induced cancellous bone loss by inhibiting osteoclast bone resorption and by a mild depression of bone turnover.

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Documento generato il 09/08/20 alle ore 22:59:37