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Titolo:
Animal-derived or synthetic surfactant for the treatment of neonatal respiratory distress syndrome: a review
Autore:
Milligan, DWA; Ainsworth, SB;
Indirizzi:
Royal Victoria Infirm, Newcastle Neonatal Serv, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and
Titolo Testata:
ACTA PAEDIATRICA
, volume: 90, anno: 2001, supplemento:, 436
pagine: 25 - 27
SICI:
0803-5253(200103)90:<25:AOSSFT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASKED COMPARISON TRIAL; NATURAL SURFACTANT; RANDOMIZED TRIAL; PRETERM RABBITS; PULMONARY SURFACTANT; EXOGENOUS SURFACTANT; RESPONSES; PROTEINS; INFANTS; LAMBS;
Keywords:
exogenous surfactant; newborn; respiratory distress syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Milligan, DWA Royal Victoria Infirm, Newcastle Neonatal Serv, Ward 35 leazes Wing, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Ward 35 leazes Wing Newcastle Upon Tyne Tyne & Wear England NE1 4LP
Citazione:
D.W.A. Milligan e S.B. Ainsworth, "Animal-derived or synthetic surfactant for the treatment of neonatal respiratory distress syndrome: a review", ACT PAEDIAT, 90, 2001, pp. 25-27

Abstract

Animal-derived surfactants containing SP-B and SP-C are more effective in vitro and in animal models than their synthetic counterparts, but are not as effective as unmodified, naturally occurring surfactant. In clinical trials involving newborn babies with respiratory distress syndrome (RDS) these short-term differences are reflected as improvements in gas exchange and lung function. Treatment with animal-derived surfactants results in fewer airleaks and lower neonatal mortality. The evidence is now strong enough to recommend routine use of animal-derived surfactants in very preterm infants with RDS. The newer generation of synthetic surfactants may be important inthe future as they have the advantages of currently available animal products with the addition of better resistance to inactivation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:13:07