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Titolo:
High cyclin E/low p27(Kip1) expression is associated with poor prognosis in astrocytomas
Autore:
Tamiya, T; Mizumatsu, S; Ono, Y; Abe, T; Matsumoto, K; Furuta, T; Ohmoto, T;
Indirizzi:
Okayama Univ, Sch Med, Dept Neurol Surg, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 t Neurol Surg, Okayama 7008558, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 4, volume: 101, anno: 2001,
pagine: 334 - 340
SICI:
0001-6322(200104)101:4<334:HCEPEI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE INHIBITOR P27; BROMODEOXYURIDINE LABELING INDEX; PROTEASOME-DEPENDENT DEGRADATION; CELL-CYCLE; BREAST-CANCER; MALIGNANT ASTROCYTOMAS; HUMAN GLIOMAS; KI-67; PROTEIN; P53;
Keywords:
astrocytoma; cyclin E; p27(Kip1); immunohistochemistry; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Tamiya, T Okayama Univ, Sch Med, Dept Neurol Surg, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 558, Japan
Citazione:
T. Tamiya et al., "High cyclin E/low p27(Kip1) expression is associated with poor prognosis in astrocytomas", ACT NEUROP, 101(4), 2001, pp. 334-340

Abstract

Cyclin E and p27(Kip1) are co-regulators of the G1-to S-phase transition and closely related to tumor behavior. The purpose of this study was to examine expression of cyclin E and p27(Kip1) in astrocytomas and to evaluate the relationships between expression of these cell-cycle regulators and prognosis of patients with astrocytoma. Tissue samples from 130 astrocytomas (WHO grade 1 n=5, grade 2 n=23, grade 3 n=64, grade 4 n=38) were examined immunohistochemically for cyclin E and p27(Kip1) expression. Patient charts were reviewed for clinical presentation, and survival was followed. The cyclinE labeling index (LI) tended to increase with tumor grade (Kruskal-Wallis,P=0.0104). Far patients with primary astrocytomas, the 50% survival times for the low cyclin E LI (<5%) group and the high cyclin E LI(<greater than or equal to>5%) group were 53.7 months and 19.8 months. In combined analysis of cyclin E and p27(Kip1) expression, the low cyclin E/high p27(Kip1) LI (greater than or equal to 50%) group had the best survival (50% survival time: 103.2 months), the low cyclin E/low p27(Kip1) LI (greater than or equalto 50%) and the high cyclin E/high p27(Kip1) LI groups moderate survival (24.1 and 27.5 months), and the high cyclin E/low p27(Kip1) LI group the worst survival (13.1 months). Multivariate analysis identified the combined factor, high cyclin E/low p27(Kip1), as a novel independent prognostic factorfor survival time (P=0.0037, relative risk=2.4). This study suggested thatcombined analysis of cyclin E and p27(Kip1) expression was considered to be potentially useful in predicting the prognosis of patients with astrocytoma.

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Documento generato il 31/10/20 alle ore 00:40:35