Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical relevance of vascular endothelial growth factor for thyroid neoplasms
Autore:
Huang, SM; Lee, JC; Wu, TJ; Chow, NH;
Indirizzi:
Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol, Tainan 704, Taiwan Natl Cheng Kung Univ Hosp Tainan Taiwan 704 t Pathol, Tainan 704, Taiwan Tzu Chi Coll Med, Dept Surg, Hualien 970, Taiwan Tzu Chi Coll Med Hualien Taiwan 970 Med, Dept Surg, Hualien 970, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Surg, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 ed, Dept Surg, Tainan 704, Taiwan Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan 704, TaiwanNatl Cheng Kung Univ Hosp Tainan Taiwan 704 rnal Med, Tainan 704, Taiwan
Titolo Testata:
WORLD JOURNAL OF SURGERY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 302 - 306
SICI:
0364-2313(200103)25:3<302:CROVEG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC SCORING SYSTEM; SQUAMOUS-CELL CARCINOMA; FACTOR EXPRESSION; TUMOR PROGRESSION; BLADDER-CANCER; FACTOR VEGF; ANGIOGENESIS; RECEPTORS; PROTEIN; STAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Chow, NH Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol, 138 Sheng Li Rd, Tainan 704, Taiwan Natl Cheng Kung Univ Hosp 138 Sheng Li Rd Tainan Taiwan 704 iwan
Citazione:
S.M. Huang et al., "Clinical relevance of vascular endothelial growth factor for thyroid neoplasms", WORLD J SUR, 25(3), 2001, pp. 302-306

Abstract

Angiogenesis is of vital importance during the development and progressionof solid tumors. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and could he produced by some cancer cells. To investigate the clinical relevance of VEGF in the tumorigenesis of human thyroid,an immunohistochemical study was performed on archival materials of follicular adenomas (n = 13), Hurthle cell adenomas (n = 6), papillary carcinomas(n = 76), follicular carcinomas (n = 12), Hurthle cell carcinomas (n = 2),and anaplastic carcinomas (n = 8). Patterns of VEGF expression were analyzed in relation to histologic subtypes of thyroid tumors and were correlatedto biologic indicators of papillary carcinoma. All papillary carcinomas and Hurthle cell neoplasms revealed a strong, diffuse staining reaction, whereas anaplastic carcinoma usually exhibited weak and infrequent immunoreactivity. VEGF levels were usually higher in follicular adenomas than in follicular carcinomas. With regard to prognostic value, VEGF expression did not correlate with tumor size, extent of invasion, or scores on the AGES system (i.e., patient age, tumor size, histologic grade, tumor extent, distant metastasis) or the MACIS system (i.e., metastasis, age, completeness of resection, invasion, tumor size) for papillary carcinomas (p > 0.05, respectively). The results of the current study indicate that VEGF may play a role in the development of human thyroid cancer. Determination of the angiogenic phenotype may have limited prognostic value for patients with papillary carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:41:00